Delirium and Obstructive Sleep Apnea: Exploring the Molecular Link
Publication
, Journal Article
Patterson, SC; Kwatra, SG; Berger, M; Kwatra, MM
Published in: Current Anesthesiology Reports
March 1, 2015
Delirium is a common problem among the elderly. The incidence of delirium will increase considerably in the coming decades as the proportion of the population over age 65 increases. Given that an FDA-approved drug to treat delirium is not available, efforts geared toward prevention are paramount. Several risk factors that predispose/precipitate delirium have been identified. A recently described, reversible risk factor for postoperative delirium is obstructive sleep apnea (OSA). In this review, we focus on the molecular basis of delirium and its link to OSA. We present evidence that OSA modulates the levels of two factors, IGF-1 and cortisol, which both have been linked to postoperative delirium.
Duke Scholars
Published In
Current Anesthesiology Reports
DOI
EISSN
1523-3855
ISSN
2167-6275
Publication Date
March 1, 2015
Volume
5
Issue
1
Start / End Page
41 / 47
Citation
APA
Chicago
ICMJE
MLA
NLM
Patterson, S. C., Kwatra, S. G., Berger, M., & Kwatra, M. M. (2015). Delirium and Obstructive Sleep Apnea: Exploring the Molecular Link. Current Anesthesiology Reports, 5(1), 41–47. https://doi.org/10.1007/s40140-014-0092-3
Patterson, S. C., S. G. Kwatra, M. Berger, and M. M. Kwatra. “Delirium and Obstructive Sleep Apnea: Exploring the Molecular Link.” Current Anesthesiology Reports 5, no. 1 (March 1, 2015): 41–47. https://doi.org/10.1007/s40140-014-0092-3.
Patterson SC, Kwatra SG, Berger M, Kwatra MM. Delirium and Obstructive Sleep Apnea: Exploring the Molecular Link. Current Anesthesiology Reports. 2015 Mar 1;5(1):41–7.
Patterson, S. C., et al. “Delirium and Obstructive Sleep Apnea: Exploring the Molecular Link.” Current Anesthesiology Reports, vol. 5, no. 1, Mar. 2015, pp. 41–47. Scopus, doi:10.1007/s40140-014-0092-3.
Patterson SC, Kwatra SG, Berger M, Kwatra MM. Delirium and Obstructive Sleep Apnea: Exploring the Molecular Link. Current Anesthesiology Reports. 2015 Mar 1;5(1):41–47.
Published In
Current Anesthesiology Reports
DOI
EISSN
1523-3855
ISSN
2167-6275
Publication Date
March 1, 2015
Volume
5
Issue
1
Start / End Page
41 / 47