Skip to main content

Epstein-Barr Virus DNAemia and post-transplant lymphoproliferative disorder in pediatric solid organ transplant recipients.

Publication ,  Journal Article
Chang, Y-C; Young, RR; Mavis, AM; Chambers, ET; Kirmani, S; Kelly, MS; Kalu, IC; Smith, MJ; Lugo, DJ
Published in: PLoS One
2022

BACKGROUND: Pediatric solid organ transplant (SOT) recipients commonly have Epstein-Barr virus (EBV) DNAemia and are at risk of developing post-transplant lymphoproliferative disorder (PTLD). EBV DNAemia has not been analyzed on a continuous scale in this population. METHODS: All children ≤ 18 years of age who underwent SOT at a single center between January 1, 2007 and July 31, 2018 were included in this retrospective study. Transplant episodes in which PTLD occurred were compared to transplant episodes without PTLD. Multivariable logistic regression was used to identify factors associated with the development of EBV DNAemia and maximum height of EBV DNAemia. A Cox proportional hazards model was used to calculate hazard ratios for time to PTLD. RESULTS: Of 275 total transplant recipients and 294 transplant episodes, there were 14 episodes of PTLD. Intestinal and multivisceral transplant were strongly associated with PTLD (p = 0.002). Risk factors for the development of EBV DNAemia include donor and recipient positive EBV serologies (p = 0.001) and older age (p = 0.001). Maximum level of EBV DNAemia was significantly associated with development of PTLD (p<0.0001). Every one log (log10) increase in the maximum level of EBV DNAemia was associated with a more than doubling of the hazard on developing PTLD (HR: 2.18, 95% CI 1.19-3.99). CONCLUSIONS: Transplant type was strongly associated with development of PTLD in pediatric SOT recipients. EBV serologies and age were associated with the development of EBV DNAemia and height of DNAemia. High levels of EBV DNAemia were strongly associated with an increased hazard for PTLD.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2022

Volume

17

Issue

10

Start / End Page

e0269766

Location

United States

Related Subject Headings

  • Transplant Recipients
  • Retrospective Studies
  • Organ Transplantation
  • Lymphoproliferative Disorders
  • Humans
  • Herpesvirus 4, Human
  • General Science & Technology
  • Epstein-Barr Virus Infections
  • DNA, Viral
  • Child
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chang, Y.-C., Young, R. R., Mavis, A. M., Chambers, E. T., Kirmani, S., Kelly, M. S., … Lugo, D. J. (2022). Epstein-Barr Virus DNAemia and post-transplant lymphoproliferative disorder in pediatric solid organ transplant recipients. PLoS One, 17(10), e0269766. https://doi.org/10.1371/journal.pone.0269766
Chang, Yeh-Chung, Rebecca R. Young, Alisha M. Mavis, Eileen T. Chambers, Sonya Kirmani, Matthew S. Kelly, Ibukunoluwa C. Kalu, Michael J. Smith, and Debra J. Lugo. “Epstein-Barr Virus DNAemia and post-transplant lymphoproliferative disorder in pediatric solid organ transplant recipients.PLoS One 17, no. 10 (2022): e0269766. https://doi.org/10.1371/journal.pone.0269766.
Chang Y-C, Young RR, Mavis AM, Chambers ET, Kirmani S, Kelly MS, et al. Epstein-Barr Virus DNAemia and post-transplant lymphoproliferative disorder in pediatric solid organ transplant recipients. PLoS One. 2022;17(10):e0269766.
Chang, Yeh-Chung, et al. “Epstein-Barr Virus DNAemia and post-transplant lymphoproliferative disorder in pediatric solid organ transplant recipients.PLoS One, vol. 17, no. 10, 2022, p. e0269766. Pubmed, doi:10.1371/journal.pone.0269766.
Chang Y-C, Young RR, Mavis AM, Chambers ET, Kirmani S, Kelly MS, Kalu IC, Smith MJ, Lugo DJ. Epstein-Barr Virus DNAemia and post-transplant lymphoproliferative disorder in pediatric solid organ transplant recipients. PLoS One. 2022;17(10):e0269766.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2022

Volume

17

Issue

10

Start / End Page

e0269766

Location

United States

Related Subject Headings

  • Transplant Recipients
  • Retrospective Studies
  • Organ Transplantation
  • Lymphoproliferative Disorders
  • Humans
  • Herpesvirus 4, Human
  • General Science & Technology
  • Epstein-Barr Virus Infections
  • DNA, Viral
  • Child