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Clinically Adjudicated Reference Standards for Evaluation of Infectious Diseases Diagnostics.

Publication ,  Journal Article
Patel, R; Tsalik, EL; Evans, S; Fowler, VG; Doernberg, SB; Antibacterial Resistance Leadership Group
Published in: Clin Infect Dis
March 4, 2023

Lack of a gold standard can present a challenge for evaluation of diagnostic test accuracy of some infectious diseases tests, particularly when the test's accuracy potentially exceeds that of its predecessors. This approach may measure agreement with an imperfect reference, rather than correctness, because the right answer is unknown. Solutions consist of multitest comparators, including those that involve a test under evaluation if multiple new tests are being evaluated together, using latent class modeling, and clinically adjudicated reference standards. Clinically adjudicated reference standards may be considered as comparator methods when no predefined test or composite of tests is sufficiently accurate; they emulate clinical practice in that multiple data pieces are clinically assessed together.

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Published In

Clin Infect Dis

DOI

EISSN

1537-6591

Publication Date

March 4, 2023

Volume

76

Issue

5

Start / End Page

938 / 943

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Reference Standards
  • Microbiology
  • Humans
  • Diagnostic Tests, Routine
  • Communicable Diseases
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Patel, R., Tsalik, E. L., Evans, S., Fowler, V. G., Doernberg, S. B., & Antibacterial Resistance Leadership Group. (2023). Clinically Adjudicated Reference Standards for Evaluation of Infectious Diseases Diagnostics. Clin Infect Dis, 76(5), 938–943. https://doi.org/10.1093/cid/ciac829
Patel, Robin, Ephraim L. Tsalik, Scott Evans, Vance G. Fowler, Sarah B. Doernberg, and Antibacterial Resistance Leadership Group. “Clinically Adjudicated Reference Standards for Evaluation of Infectious Diseases Diagnostics.Clin Infect Dis 76, no. 5 (March 4, 2023): 938–43. https://doi.org/10.1093/cid/ciac829.
Patel R, Tsalik EL, Evans S, Fowler VG, Doernberg SB, Antibacterial Resistance Leadership Group. Clinically Adjudicated Reference Standards for Evaluation of Infectious Diseases Diagnostics. Clin Infect Dis. 2023 Mar 4;76(5):938–43.
Patel, Robin, et al. “Clinically Adjudicated Reference Standards for Evaluation of Infectious Diseases Diagnostics.Clin Infect Dis, vol. 76, no. 5, Mar. 2023, pp. 938–43. Pubmed, doi:10.1093/cid/ciac829.
Patel R, Tsalik EL, Evans S, Fowler VG, Doernberg SB, Antibacterial Resistance Leadership Group. Clinically Adjudicated Reference Standards for Evaluation of Infectious Diseases Diagnostics. Clin Infect Dis. 2023 Mar 4;76(5):938–943.
Journal cover image

Published In

Clin Infect Dis

DOI

EISSN

1537-6591

Publication Date

March 4, 2023

Volume

76

Issue

5

Start / End Page

938 / 943

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Reference Standards
  • Microbiology
  • Humans
  • Diagnostic Tests, Routine
  • Communicable Diseases
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences
  • 06 Biological Sciences