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Systematic review and meta-analysis of the effect of adverse childhood experiences (ACEs) on brain-derived neurotrophic factor (BDNF) levels.

Publication ,  Journal Article
Vyas, N; Wimberly, CE; Beaman, MM; Kaplan, SJ; Rasmussen, LJH; Wertz, J; Gifford, EJ; Walsh, KM
Published in: Psychoneuroendocrinology
May 2023

There is continued interest in identifying dysregulated biomarkers that mediate associations between adverse childhood experiences (ACEs) and negative long-term health outcomes. However, little is known regarding how ACE exposure modulates neural biomarkers to influence poorer health outcomes in ACE-exposed children. To address this, we performed a systematic review and meta-analysis of the impact of ACE exposure on Brain Derived Neurotrophic Factor (BDNF) levels - a neural biomarker involved in childhood and adult neurogenesis and long-term memory formation. Twenty-two studies were selected for inclusion within the systematic review, ten of which were included in meta-analysis. Most included studies retrospectively assessed impacts of childhood maltreatment in clinical populations. Sample size, BDNF protein levels in ACE-exposed and unexposed subjects, and standard deviations were extracted from ten publications to estimate the BDNF ratio of means (ROM) across exposure categories. Overall, no significant difference was found in BDNF protein levels between ACE-exposed and unexposed groups (ROM: 1.08; 95 % CI: 0.93-1.26). Age at sampling, analyte type (e.g., sera, plasma, blood), and categories of ACE exposure contributed to high between-study heterogeneity, some of which was minimized in subset-based analyses. These results support continued investigation into the impact of ACE exposure on neural biomarkers and highlight the potential importance of analyte type and timing of sample collection on study results.

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Published In

Psychoneuroendocrinology

DOI

EISSN

1873-3360

Publication Date

May 2023

Volume

151

Start / End Page

106071

Location

England

Related Subject Headings

  • Retrospective Studies
  • Psychiatry
  • Humans
  • Child
  • Brain-Derived Neurotrophic Factor
  • Biomarkers
  • Adverse Childhood Experiences
  • Adult
  • 52 Psychology
  • 32 Biomedical and clinical sciences
 

Citation

APA
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ICMJE
MLA
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Vyas, N., Wimberly, C. E., Beaman, M. M., Kaplan, S. J., Rasmussen, L. J. H., Wertz, J., … Walsh, K. M. (2023). Systematic review and meta-analysis of the effect of adverse childhood experiences (ACEs) on brain-derived neurotrophic factor (BDNF) levels. Psychoneuroendocrinology, 151, 106071. https://doi.org/10.1016/j.psyneuen.2023.106071
Vyas, Neha, Courtney E. Wimberly, M Makenzie Beaman, Samantha J. Kaplan, Line J. H. Rasmussen, Jasmin Wertz, Elizabeth J. Gifford, and Kyle M. Walsh. “Systematic review and meta-analysis of the effect of adverse childhood experiences (ACEs) on brain-derived neurotrophic factor (BDNF) levels.Psychoneuroendocrinology 151 (May 2023): 106071. https://doi.org/10.1016/j.psyneuen.2023.106071.
Vyas N, Wimberly CE, Beaman MM, Kaplan SJ, Rasmussen LJH, Wertz J, et al. Systematic review and meta-analysis of the effect of adverse childhood experiences (ACEs) on brain-derived neurotrophic factor (BDNF) levels. Psychoneuroendocrinology. 2023 May;151:106071.
Vyas, Neha, et al. “Systematic review and meta-analysis of the effect of adverse childhood experiences (ACEs) on brain-derived neurotrophic factor (BDNF) levels.Psychoneuroendocrinology, vol. 151, May 2023, p. 106071. Pubmed, doi:10.1016/j.psyneuen.2023.106071.
Vyas N, Wimberly CE, Beaman MM, Kaplan SJ, Rasmussen LJH, Wertz J, Gifford EJ, Walsh KM. Systematic review and meta-analysis of the effect of adverse childhood experiences (ACEs) on brain-derived neurotrophic factor (BDNF) levels. Psychoneuroendocrinology. 2023 May;151:106071.
Journal cover image

Published In

Psychoneuroendocrinology

DOI

EISSN

1873-3360

Publication Date

May 2023

Volume

151

Start / End Page

106071

Location

England

Related Subject Headings

  • Retrospective Studies
  • Psychiatry
  • Humans
  • Child
  • Brain-Derived Neurotrophic Factor
  • Biomarkers
  • Adverse Childhood Experiences
  • Adult
  • 52 Psychology
  • 32 Biomedical and clinical sciences