Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Self-reported gastrointestinal disorders among veterans with gulf war illness with and without posttraumatic stress disorder.

Publication ,  Journal Article
Malhotra, D; Boyle, SH; Gifford, EJ; Sullivan, BA; Nguyen Wenker, TH; Abs, N-D; Ahmed, ST; Upchurch, J; Vahey, J; Stafford, C; Efird, JT ...
Published in: Neurogastroenterol Motil
May 2023

BACKGROUND: Gulf War Illness (GWI) is a chronic, multi-symptom disorder affecting 25%-32% of Gulf War veterans. Veterans with GWI disproportionately suffer from gastrointestinal (GI) disorders. Given the increasing evidence supporting a gut-brain axis, we explore the relationship between post-traumatic stress disorder (PTSD), GWI, and self-reported GI disorders among GW veterans. METHODS: Veterans from the Gulf War Era Cohort and Biorepository responded to a mail-based survey (N = 1058). They were stratified by GWI (Centers for Disease Control definition) and PTSD status. This yielded three groups: GWI-, GWI+/PTSD-, and GWI+/PTSD+. Multivariable logistic regression adjusting for demographic and military characteristics examined associations between GWI/PTSD groups and GI disorders. Results were expressed as adjusted odds ratios (aOR) with 95% confidence intervals (95% CI). KEY RESULTS: The most frequently reported GI disorders were irritable bowel syndrome (IBS), gastroesophageal reflux disease (GERD), and colon polyps (CP). The GWI+/PTSD+ group had a higher odds of these disorders than the GWI+/PTSD- group (aORIBS  = 3.12, 95% CI: 1.93-5.05; aORGERD  = 2.04, 95% CI: 1.44-2.90; aORCP  = 1.85, 95% CI: 1.23-2.80), which had a higher odds of these disorders than the GWI- group (aORIBS  = 4.38, 95% CI: 1.55-12.36; aORGERD  = 2.51 95% CI: 1.63-3.87; aORCP  = 2.57, 95% CI: 1.53-4.32). CONCLUSIONS & INFERENCES: GW veterans with GWI and PTSD have significantly higher odds of specific self-reported GI disorders than the other groups. Given the known bidirectional influences of the gut and brain, these veterans may benefit from a holistic healthcare approach that considers biopsychosocial contributors to the assessment and management of disease.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Neurogastroenterol Motil

DOI

EISSN

1365-2982

Publication Date

May 2023

Volume

35

Issue

5

Start / End Page

e14548

Location

England

Related Subject Headings

  • Veterans
  • Stress Disorders, Post-Traumatic
  • Self Report
  • Persian Gulf Syndrome
  • Irritable Bowel Syndrome
  • Humans
  • Gulf War
  • Gastrointestinal Diseases
  • Gastroesophageal Reflux
  • Gastroenterology & Hepatology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Malhotra, D., Boyle, S. H., Gifford, E. J., Sullivan, B. A., Nguyen Wenker, T. H., Abs, N.-D., … Williams, C. D. (2023). Self-reported gastrointestinal disorders among veterans with gulf war illness with and without posttraumatic stress disorder. Neurogastroenterol Motil, 35(5), e14548. https://doi.org/10.1111/nmo.14548
Malhotra, D., S. H. Boyle, E. J. Gifford, B. A. Sullivan, T. H. Nguyen Wenker, Nono-Djotsa Abs, S. T. Ahmed, et al. “Self-reported gastrointestinal disorders among veterans with gulf war illness with and without posttraumatic stress disorder.Neurogastroenterol Motil 35, no. 5 (May 2023): e14548. https://doi.org/10.1111/nmo.14548.
Malhotra D, Boyle SH, Gifford EJ, Sullivan BA, Nguyen Wenker TH, Abs N-D, et al. Self-reported gastrointestinal disorders among veterans with gulf war illness with and without posttraumatic stress disorder. Neurogastroenterol Motil. 2023 May;35(5):e14548.
Malhotra, D., et al. “Self-reported gastrointestinal disorders among veterans with gulf war illness with and without posttraumatic stress disorder.Neurogastroenterol Motil, vol. 35, no. 5, May 2023, p. e14548. Pubmed, doi:10.1111/nmo.14548.
Malhotra D, Boyle SH, Gifford EJ, Sullivan BA, Nguyen Wenker TH, Abs N-D, Ahmed ST, Upchurch J, Vahey J, Stafford C, Efird JT, Hunt SC, Bradford A, Sims KJ, Hauser ER, Helmer DA, Williams CD. Self-reported gastrointestinal disorders among veterans with gulf war illness with and without posttraumatic stress disorder. Neurogastroenterol Motil. 2023 May;35(5):e14548.
Journal cover image

Published In

Neurogastroenterol Motil

DOI

EISSN

1365-2982

Publication Date

May 2023

Volume

35

Issue

5

Start / End Page

e14548

Location

England

Related Subject Headings

  • Veterans
  • Stress Disorders, Post-Traumatic
  • Self Report
  • Persian Gulf Syndrome
  • Irritable Bowel Syndrome
  • Humans
  • Gulf War
  • Gastrointestinal Diseases
  • Gastroesophageal Reflux
  • Gastroenterology & Hepatology