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Survival and tumor characteristics of patients presenting with single primary versus second primary melanoma lesions.

Publication ,  Journal Article
Sarver, MM; Rames, JD; Beasley, GM; Gao, J; Jung, S-H; Chen, SC
Published in: J Am Acad Dermatol
May 2023

BACKGROUND: Patients with single primary melanomas have an increased risk of developing subsequent melanomas. Secondary tumors diagnosed within and after 3 months are termed "synchronous" and "asynchronous," respectively. OBJECTIVE: To compare tumor distributions and survival characteristics between patients with second primary melanomas and those with single primary melanomas. METHODS: Retrospective cohort study. Data were collected from an institutional database from 14,029 patients with a diagnosis of a primary melanoma seen between 1970 and 2004. RESULTS: The synchronous and asynchronous cohorts demonstrated significantly improved survival probabilities compared with the single primary cohort (P = .04 and .002, respectively). Single primary lesions (2.2 ± 2.3 mm) were significantly thicker than the first-identified synchronous (2.0 ± 1.7 mm) and asynchronous (1.7 ± 1.3 mm) lesions. Synchronous lesions were more likely to be anatomically concordant compared with asynchronous lesions (55.7% vs 38.2%, P < .001). LIMITATIONS: Single-center study design and incomplete records for second primary melanoma Breslow depth and histopathology. CONCLUSION: Patients with second primary melanomas demonstrated a significant survival advantage and thinner lesions compared with those with single primary melanomas. Our reported tumor distributions support the role of full body skin examinations, with attention to the region of initial diagnosis.

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Published In

J Am Acad Dermatol

DOI

EISSN

1097-6787

Publication Date

May 2023

Volume

88

Issue

5

Start / End Page

1033 / 1039

Location

United States

Related Subject Headings

  • Skin Neoplasms
  • Retrospective Studies
  • Physical Examination
  • Melanoma
  • Humans
  • Dermatology & Venereal Diseases
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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ICMJE
MLA
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Sarver, M. M., Rames, J. D., Beasley, G. M., Gao, J., Jung, S.-H., & Chen, S. C. (2023). Survival and tumor characteristics of patients presenting with single primary versus second primary melanoma lesions. J Am Acad Dermatol, 88(5), 1033–1039. https://doi.org/10.1016/j.jaad.2022.04.046
Sarver, Melissa M., Jess D. Rames, Georgia M. Beasley, Junheng Gao, Sin-Ho Jung, and Suephy C. Chen. “Survival and tumor characteristics of patients presenting with single primary versus second primary melanoma lesions.J Am Acad Dermatol 88, no. 5 (May 2023): 1033–39. https://doi.org/10.1016/j.jaad.2022.04.046.
Sarver MM, Rames JD, Beasley GM, Gao J, Jung S-H, Chen SC. Survival and tumor characteristics of patients presenting with single primary versus second primary melanoma lesions. J Am Acad Dermatol. 2023 May;88(5):1033–9.
Sarver, Melissa M., et al. “Survival and tumor characteristics of patients presenting with single primary versus second primary melanoma lesions.J Am Acad Dermatol, vol. 88, no. 5, May 2023, pp. 1033–39. Pubmed, doi:10.1016/j.jaad.2022.04.046.
Sarver MM, Rames JD, Beasley GM, Gao J, Jung S-H, Chen SC. Survival and tumor characteristics of patients presenting with single primary versus second primary melanoma lesions. J Am Acad Dermatol. 2023 May;88(5):1033–1039.
Journal cover image

Published In

J Am Acad Dermatol

DOI

EISSN

1097-6787

Publication Date

May 2023

Volume

88

Issue

5

Start / End Page

1033 / 1039

Location

United States

Related Subject Headings

  • Skin Neoplasms
  • Retrospective Studies
  • Physical Examination
  • Melanoma
  • Humans
  • Dermatology & Venereal Diseases
  • 3202 Clinical sciences
  • 1103 Clinical Sciences