Estimating a brain network predictive of stress and genotype with supervised autoencoders.
Publication
, Journal Article
Talbot, A; Dunson, D; Dzirasa, K; Carlson, D
Published in: J R Stat Soc Ser C Appl Stat
August 2023
Targeted brain stimulation has the potential to treat mental illnesses. We develop an approach to help design protocols by identifying relevant multi-region electrical dynamics. Our approach models these dynamics as a superposition of latent networks, where the latent variables predict a relevant outcome. We use supervised autoencoders (SAEs) to improve predictive performance in this context, describe the conditions where SAEs improve predictions, and provide modelling constraints to ensure biological relevance. We experimentally validate our approach by finding a network associated with stress that aligns with a previous stimulation protocol and characterizing a genotype associated with bipolar disorder.
Duke Scholars
Published In
J R Stat Soc Ser C Appl Stat
DOI
ISSN
0035-9254
Publication Date
August 2023
Volume
72
Issue
4
Start / End Page
912 / 936
Location
England
Related Subject Headings
- Statistics & Probability
- 4905 Statistics
- 0104 Statistics
Citation
APA
Chicago
ICMJE
MLA
NLM
Talbot, A., Dunson, D., Dzirasa, K., & Carlson, D. (2023). Estimating a brain network predictive of stress and genotype with supervised autoencoders. J R Stat Soc Ser C Appl Stat, 72(4), 912–936. https://doi.org/10.1093/jrsssc/qlad035
Talbot, Austin, David Dunson, Kafui Dzirasa, and David Carlson. “Estimating a brain network predictive of stress and genotype with supervised autoencoders.” J R Stat Soc Ser C Appl Stat 72, no. 4 (August 2023): 912–36. https://doi.org/10.1093/jrsssc/qlad035.
Talbot A, Dunson D, Dzirasa K, Carlson D. Estimating a brain network predictive of stress and genotype with supervised autoencoders. J R Stat Soc Ser C Appl Stat. 2023 Aug;72(4):912–36.
Talbot, Austin, et al. “Estimating a brain network predictive of stress and genotype with supervised autoencoders.” J R Stat Soc Ser C Appl Stat, vol. 72, no. 4, Aug. 2023, pp. 912–36. Pubmed, doi:10.1093/jrsssc/qlad035.
Talbot A, Dunson D, Dzirasa K, Carlson D. Estimating a brain network predictive of stress and genotype with supervised autoencoders. J R Stat Soc Ser C Appl Stat. 2023 Aug;72(4):912–936.
Published In
J R Stat Soc Ser C Appl Stat
DOI
ISSN
0035-9254
Publication Date
August 2023
Volume
72
Issue
4
Start / End Page
912 / 936
Location
England
Related Subject Headings
- Statistics & Probability
- 4905 Statistics
- 0104 Statistics