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The association of female sex with management and mortality in patients with Staphylococcus aureus bacteraemia.

Publication ,  Journal Article
Westgeest, AC; Ruffin, F; Kair, JL; Park, LP; Korn, RE; Webster, ME; Visser, LG; Schippers, EF; de Boer, MGJ; Lambregts, MMC; Fowler, VG
Published in: Clin Microbiol Infect
September 2023

OBJECTIVES: The association of biological female sex with outcome in patients with Staphylococcus aureus bacteraemia remains unresolved. The aim of this study was to determine the independent association of female sex with management and mortality in patients with S. aureus bacteraemia. METHODS: This is a post hoc analysis of prospectively collected data from the S. aureus Bacteraemia Group Prospective Cohort Study. Adult patients with monomicrobial S. aureus bacteraemia at Duke University Medical Center were enrolled from 1994 to 2020. Univariable and multivariable Cox regression analyses were performed to assess differences in management and mortality between females and males. RESULTS: Among 3384 patients with S. aureus bacteraemia, 1431 (42%) were women. Women were, as compared with men, more often Black (581/1431 [41%] vs. 620/1953 [32%], p < 0.001), haemodialysis dependent (309/1424 [22%] vs. 334/1940 [17%], p 0.001) and more likely to be infected with methicillin-resistant S. aureus (MRSA) (697/1410 [49%] MRSA in women vs. 840/1925 [44%] MRSA in men, p 0.001). Women received shorter durations of antimicrobial treatment (median 24 [interquartile range 14-42] vs. 28 [interquartile range 14-45] days, p 0.005), and were less likely to undergo transesophageal echocardiography as compared with men (495/1430 [35%] vs. 802/1952 [41%], p < 0.001). Despite these differences, female sex was not associated with 90-day mortality in either univariable (388/1431 [27%] in women vs. 491/1953 [25%] in men, p 0.204) or multivariable analysis (adjusted hazard ratio for women 0.98 [95% CI, 0.85-1.13]). DISCUSSION: Despite significant differences in patient characteristics, disease characteristics, and management, women and men with S. aureus bacteraemia have a similar mortality risk.

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Published In

Clin Microbiol Infect

DOI

EISSN

1469-0691

Publication Date

September 2023

Volume

29

Issue

9

Start / End Page

1182 / 1187

Location

England

Related Subject Headings

  • Staphylococcus aureus
  • Staphylococcal Infections
  • Prospective Studies
  • Microbiology
  • Methicillin-Resistant Staphylococcus aureus
  • Male
  • Humans
  • Female
  • Bacteremia
  • Anti-Bacterial Agents
 

Citation

APA
Chicago
ICMJE
MLA
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Westgeest, A. C., Ruffin, F., Kair, J. L., Park, L. P., Korn, R. E., Webster, M. E., … Fowler, V. G. (2023). The association of female sex with management and mortality in patients with Staphylococcus aureus bacteraemia. Clin Microbiol Infect, 29(9), 1182–1187. https://doi.org/10.1016/j.cmi.2023.06.009
Westgeest, Annette C., Felicia Ruffin, Jackson L. Kair, Lawrence P. Park, Rachel E. Korn, Maren E. Webster, Leo G. Visser, et al. “The association of female sex with management and mortality in patients with Staphylococcus aureus bacteraemia.Clin Microbiol Infect 29, no. 9 (September 2023): 1182–87. https://doi.org/10.1016/j.cmi.2023.06.009.
Westgeest AC, Ruffin F, Kair JL, Park LP, Korn RE, Webster ME, et al. The association of female sex with management and mortality in patients with Staphylococcus aureus bacteraemia. Clin Microbiol Infect. 2023 Sep;29(9):1182–7.
Westgeest, Annette C., et al. “The association of female sex with management and mortality in patients with Staphylococcus aureus bacteraemia.Clin Microbiol Infect, vol. 29, no. 9, Sept. 2023, pp. 1182–87. Pubmed, doi:10.1016/j.cmi.2023.06.009.
Westgeest AC, Ruffin F, Kair JL, Park LP, Korn RE, Webster ME, Visser LG, Schippers EF, de Boer MGJ, Lambregts MMC, Fowler VG. The association of female sex with management and mortality in patients with Staphylococcus aureus bacteraemia. Clin Microbiol Infect. 2023 Sep;29(9):1182–1187.
Journal cover image

Published In

Clin Microbiol Infect

DOI

EISSN

1469-0691

Publication Date

September 2023

Volume

29

Issue

9

Start / End Page

1182 / 1187

Location

England

Related Subject Headings

  • Staphylococcus aureus
  • Staphylococcal Infections
  • Prospective Studies
  • Microbiology
  • Methicillin-Resistant Staphylococcus aureus
  • Male
  • Humans
  • Female
  • Bacteremia
  • Anti-Bacterial Agents