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PFAS levels in paired drinking water and serum samples collected from an exposed community in Central North Carolina.

Publication ,  Journal Article
Hall, SM; Zhang, S; Tait, GH; Hoffman, K; Collier, DN; Hoppin, JA; Stapleton, HM
Published in: The Science of the total environment
October 2023

The community of Pittsboro, North Carolina has been documented to have extensive per- and polyfluoroalkyl substances (PFAS) contamination in its drinking water source, the Haw River, over the last 20 years. However, a detailed exposure assessment has never been conducted. In this study, we sought to characterize the PFAS in paired drinking water and blood samples collected from a small cohort of Pittsboro residents (n = 49). Drinking water and serum from blood were collected from adults in late 2019 and early 2020 and were analyzed to quantify 13 PFAS analytes. In order to explore potential health effects of PFAS exposure, serum was further analyzed for clinical chemistry endpoints that could be potentially associated with PFAS (e.g., cholesterol, liver function biomarkers). PFAS were detected in all serum samples, and some serum PFAS concentrations were 2 to 4 times higher than the median U.S. serum concentrations reported in the general U.S. population. Of the 13 PFAS in drinking water, perfluorohexanoic acid (PFHxA) was measured at the highest concentrations. PFAS levels in the current drinking water were not associated with current serum PFAS, suggesting that the serum PFAS in this cohort likely reflects historical exposure to PFAS with long half-lives (e.g., PFOS and PFOA). However, one PFAS with a shorter half-life (PFHxA) was observed to increase in serum, reflecting the temporal variability of PFHxA in river and drinking water. Statistical analyses indicated that serum PFOA and PFHxS were positively associated with total cholesterol and non-HDL cholesterol. No serum PFAS was associated with HDL cholesterol. In the clinical chemistry analyses, serum PFHxA was found to be negatively associated with electrolytes and liver enzymes (e.g., AST and ALT), and serum PFOS was found to be positively associated with the ratio of blood urea nitrogen to creatinine (BUN:Cre). While small in size, this study revealed extensive exposure to PFAS in Pittsboro and associations with clinical blood markers, suggesting potential health impacts in community residents.

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Published In

The Science of the total environment

DOI

EISSN

1879-1026

ISSN

0048-9697

Publication Date

October 2023

Volume

895

Start / End Page

165091

Related Subject Headings

  • Water Pollutants, Chemical
  • North Carolina
  • Humans
  • Fluorocarbons
  • Environmental Sciences
  • Drinking Water
  • Caprylates
  • Alkanesulfonic Acids
  • Adult
 

Citation

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Hall, S. M., Zhang, S., Tait, G. H., Hoffman, K., Collier, D. N., Hoppin, J. A., & Stapleton, H. M. (2023). PFAS levels in paired drinking water and serum samples collected from an exposed community in Central North Carolina. The Science of the Total Environment, 895, 165091. https://doi.org/10.1016/j.scitotenv.2023.165091
Hall, Samantha M., Sharon Zhang, George H. Tait, Kate Hoffman, David N. Collier, Jane A. Hoppin, and Heather M. Stapleton. “PFAS levels in paired drinking water and serum samples collected from an exposed community in Central North Carolina.The Science of the Total Environment 895 (October 2023): 165091. https://doi.org/10.1016/j.scitotenv.2023.165091.
Hall SM, Zhang S, Tait GH, Hoffman K, Collier DN, Hoppin JA, et al. PFAS levels in paired drinking water and serum samples collected from an exposed community in Central North Carolina. The Science of the total environment. 2023 Oct;895:165091.
Hall, Samantha M., et al. “PFAS levels in paired drinking water and serum samples collected from an exposed community in Central North Carolina.The Science of the Total Environment, vol. 895, Oct. 2023, p. 165091. Epmc, doi:10.1016/j.scitotenv.2023.165091.
Hall SM, Zhang S, Tait GH, Hoffman K, Collier DN, Hoppin JA, Stapleton HM. PFAS levels in paired drinking water and serum samples collected from an exposed community in Central North Carolina. The Science of the total environment. 2023 Oct;895:165091.
Journal cover image

Published In

The Science of the total environment

DOI

EISSN

1879-1026

ISSN

0048-9697

Publication Date

October 2023

Volume

895

Start / End Page

165091

Related Subject Headings

  • Water Pollutants, Chemical
  • North Carolina
  • Humans
  • Fluorocarbons
  • Environmental Sciences
  • Drinking Water
  • Caprylates
  • Alkanesulfonic Acids
  • Adult