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Immunogenicity of a 2-Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial.

Publication ,  Journal Article
Rouphael, NG; Branche, AR; Diemert, DJ; Falsey, AR; Losada, C; Baden, LR; Frey, SE; Whitaker, JA; Little, SJ; Kamidani, S; Walter, EB; Rupp, R ...
Published in: J Infect Dis
December 20, 2023

We compared the serologic responses of 1 dose versus 2 doses of a variant vaccine (Moderna mRNA-1273 Beta/Omicron BA.1 bivalent vaccine) in adults. A 2-dose boosting regimen with a variant vaccine did not increase the magnitude or the durability of the serological responses compared to a single variant vaccine boost.

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Published In

J Infect Dis

DOI

EISSN

1537-6613

Publication Date

December 20, 2023

Volume

228

Issue

12

Start / End Page

1662 / 1666

Location

United States

Related Subject Headings

  • Vaccines, Combined
  • RNA, Messenger
  • Microbiology
  • Humans
  • Clinical Protocols
  • Adult
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 2019-nCoV Vaccine mRNA-1273
 

Citation

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Rouphael, N. G., Branche, A. R., Diemert, D. J., Falsey, A. R., Losada, C., Baden, L. R., … Coronavirus Variant Immunologic Landscape Trial (COVAIL) Study Team. (2023). Immunogenicity of a 2-Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial. J Infect Dis, 228(12), 1662–1666. https://doi.org/10.1093/infdis/jiad323
Rouphael, Nadine G., Angela R. Branche, David J. Diemert, Ann R. Falsey, Cecilia Losada, Lindsey R. Baden, Sharon E. Frey, et al. “Immunogenicity of a 2-Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial.J Infect Dis 228, no. 12 (December 20, 2023): 1662–66. https://doi.org/10.1093/infdis/jiad323.
Rouphael NG, Branche AR, Diemert DJ, Falsey AR, Losada C, Baden LR, et al. Immunogenicity of a 2-Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial. J Infect Dis. 2023 Dec 20;228(12):1662–6.
Rouphael, Nadine G., et al. “Immunogenicity of a 2-Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial.J Infect Dis, vol. 228, no. 12, Dec. 2023, pp. 1662–66. Pubmed, doi:10.1093/infdis/jiad323.
Rouphael NG, Branche AR, Diemert DJ, Falsey AR, Losada C, Baden LR, Frey SE, Whitaker JA, Little SJ, Kamidani S, Walter EB, Novak RM, Rupp R, Jackson LA, Babu TM, Kottkamp AC, Luetkemeyer AF, Immergluck LC, Presti RM, Bäcker M, Winokur PL, Mahgoub SM, Goepfert PA, Fusco DN, Atmar RL, Posavad CM, Netzl A, Smith DJ, Telu K, Mu J, McQuarrie LJ, Makowski M, Makhene MK, Crandon S, Montefiori DC, Roberts PC, Beigel JH, Coronavirus Variant Immunologic Landscape Trial (COVAIL) Study Team. Immunogenicity of a 2-Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial. J Infect Dis. 2023 Dec 20;228(12):1662–1666.
Journal cover image

Published In

J Infect Dis

DOI

EISSN

1537-6613

Publication Date

December 20, 2023

Volume

228

Issue

12

Start / End Page

1662 / 1666

Location

United States

Related Subject Headings

  • Vaccines, Combined
  • RNA, Messenger
  • Microbiology
  • Humans
  • Clinical Protocols
  • Adult
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 2019-nCoV Vaccine mRNA-1273