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Characterization of βARKct engineered cellular extracellular vesicles and model specific cardioprotection

Publication ,  Journal Article
Kwon, J-S; Schumacher, SM; Gao, E; Chuprun, JK; Ibetti, J; Roy, R; Khan, M; Kishore, R; Koch, WJ
Published in: American Journal of Physiology-Heart and Circulatory Physiology
April 1, 2021

βARKct, the peptide inhibitor of GRK2, improves survival and metabolic functions of cardiac-derived progenitor cells. As any benefit of stem cells in the ischemic and injured heart suggests paracrine mechanisms via secreted EVs, we investigated whether CDC-βARKct engineered EVs would show any benefit over control CDC-EVs. Compared with control EVs, βARKct-containing EVs displayed some unique beneficial properties that may be due to altered pro- and anti-inflammatory cytokines within the vesicles.

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Published In

American Journal of Physiology-Heart and Circulatory Physiology

DOI

EISSN

1522-1539

ISSN

0363-6135

Publication Date

April 1, 2021

Volume

320

Issue

4

Start / End Page

H1276 / H1289

Publisher

American Physiological Society

Related Subject Headings

  • Cardiovascular System & Hematology
  • 3208 Medical physiology
  • 3201 Cardiovascular medicine and haematology
  • 1116 Medical Physiology
  • 0606 Physiology
 

Citation

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Kwon, J.-S., Schumacher, S. M., Gao, E., Chuprun, J. K., Ibetti, J., Roy, R., … Koch, W. J. (2021). Characterization of βARKct engineered cellular extracellular vesicles and model specific cardioprotection. American Journal of Physiology-Heart and Circulatory Physiology, 320(4), H1276–H1289. https://doi.org/10.1152/ajpheart.00571.2020
Kwon, Jin-Sook, Sarah M. Schumacher, Erhe Gao, J Kurt Chuprun, Jessica Ibetti, Rajika Roy, Mohsin Khan, Raj Kishore, and Walter J. Koch. “Characterization of βARKct engineered cellular extracellular vesicles and model specific cardioprotection.” American Journal of Physiology-Heart and Circulatory Physiology 320, no. 4 (April 1, 2021): H1276–89. https://doi.org/10.1152/ajpheart.00571.2020.
Kwon J-S, Schumacher SM, Gao E, Chuprun JK, Ibetti J, Roy R, et al. Characterization of βARKct engineered cellular extracellular vesicles and model specific cardioprotection. American Journal of Physiology-Heart and Circulatory Physiology. 2021 Apr 1;320(4):H1276–89.
Kwon, Jin-Sook, et al. “Characterization of βARKct engineered cellular extracellular vesicles and model specific cardioprotection.” American Journal of Physiology-Heart and Circulatory Physiology, vol. 320, no. 4, American Physiological Society, Apr. 2021, pp. H1276–89. Crossref, doi:10.1152/ajpheart.00571.2020.
Kwon J-S, Schumacher SM, Gao E, Chuprun JK, Ibetti J, Roy R, Khan M, Kishore R, Koch WJ. Characterization of βARKct engineered cellular extracellular vesicles and model specific cardioprotection. American Journal of Physiology-Heart and Circulatory Physiology. American Physiological Society; 2021 Apr 1;320(4):H1276–H1289.

Published In

American Journal of Physiology-Heart and Circulatory Physiology

DOI

EISSN

1522-1539

ISSN

0363-6135

Publication Date

April 1, 2021

Volume

320

Issue

4

Start / End Page

H1276 / H1289

Publisher

American Physiological Society

Related Subject Headings

  • Cardiovascular System & Hematology
  • 3208 Medical physiology
  • 3201 Cardiovascular medicine and haematology
  • 1116 Medical Physiology
  • 0606 Physiology