Vaccination Against Pneumonia May Provide Genotype-Specific Protection Against Alzheimer's Disease.
Publication
, Journal Article
Ukraintseva, S; Duan, M; Simanek, AM; Holmes, R; Bagley, O; Rajendrakumar, AL; Yashkin, AP; Akushevich, I; Tropsha, A; Whitson, H; Yashin, A ...
Published in: J Alzheimers Dis
2023
Vaccine repurposing that considers individual genotype may aid personalized prevention of Alzheimer's disease (AD). In this retrospective cohort study, we used Cardiovascular Health Study data to estimate associations of pneumococcal polysaccharide vaccine and flu shots received between ages 65-75 with AD onset at age 75 or older, taking into account rs6859 polymorphism in NECTIN2 gene (AD risk factor). Pneumococcal vaccine, and total count of vaccinations against pneumonia and flu, were associated with lower odds of AD in carriers of rs6859 A allele, but not in non-carriers. We conclude that pneumococcal polysaccharide vaccine is a promising candidate for genotype-tailored AD prevention.
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Published In
J Alzheimers Dis
DOI
EISSN
1875-8908
Publication Date
2023
Volume
96
Issue
2
Start / End Page
499 / 505
Location
United States
Related Subject Headings
- Vaccination
- Retrospective Studies
- Pneumonia, Pneumococcal
- Pneumococcal Vaccines
- Neurology & Neurosurgery
- Humans
- Genotype
- Alzheimer Disease
- Aged
- 5202 Biological psychology
Citation
APA
Chicago
ICMJE
MLA
NLM
Ukraintseva, S., Duan, M., Simanek, A. M., Holmes, R., Bagley, O., Rajendrakumar, A. L., … Arbeev, K. (2023). Vaccination Against Pneumonia May Provide Genotype-Specific Protection Against Alzheimer's Disease. J Alzheimers Dis, 96(2), 499–505. https://doi.org/10.3233/JAD-230088
Ukraintseva, Svetlana, Matt Duan, Amanda M. Simanek, Rachel Holmes, Olivia Bagley, Aravind L. Rajendrakumar, Arseniy P. Yashkin, et al. “Vaccination Against Pneumonia May Provide Genotype-Specific Protection Against Alzheimer's Disease.” J Alzheimers Dis 96, no. 2 (2023): 499–505. https://doi.org/10.3233/JAD-230088.
Ukraintseva S, Duan M, Simanek AM, Holmes R, Bagley O, Rajendrakumar AL, et al. Vaccination Against Pneumonia May Provide Genotype-Specific Protection Against Alzheimer's Disease. J Alzheimers Dis. 2023;96(2):499–505.
Ukraintseva, Svetlana, et al. “Vaccination Against Pneumonia May Provide Genotype-Specific Protection Against Alzheimer's Disease.” J Alzheimers Dis, vol. 96, no. 2, 2023, pp. 499–505. Pubmed, doi:10.3233/JAD-230088.
Ukraintseva S, Duan M, Simanek AM, Holmes R, Bagley O, Rajendrakumar AL, Yashkin AP, Akushevich I, Tropsha A, Whitson H, Yashin A, Arbeev K. Vaccination Against Pneumonia May Provide Genotype-Specific Protection Against Alzheimer's Disease. J Alzheimers Dis. 2023;96(2):499–505.
Published In
J Alzheimers Dis
DOI
EISSN
1875-8908
Publication Date
2023
Volume
96
Issue
2
Start / End Page
499 / 505
Location
United States
Related Subject Headings
- Vaccination
- Retrospective Studies
- Pneumonia, Pneumococcal
- Pneumococcal Vaccines
- Neurology & Neurosurgery
- Humans
- Genotype
- Alzheimer Disease
- Aged
- 5202 Biological psychology