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Hybrid spiral scanning in a double-clad fiber-based handheld confocal scanning light ophthalmoscope.

Publication ,  Journal Article
Wei, F; Hagan, K; Viehland, C; Tao, YK; Kuo, AN; Izatt, JA; Dhalla, A-H
Published in: Biomed Opt Express
October 1, 2023

High-speed, accessible, and robust in vivo imaging of the human retina is critical for screening of retinal pathologies, such as diabetic retinopathy, age-related macular degeneration, and others. Scanning light ophthalmoscopy (SLO) is a retinal imaging modality that produces digital, en face images of the human retina with superior image gradability rates when compared to the current standard of care in screening for these diseases, namely the flood-illumination handheld fundus camera (HFC). However, current-generation commercial SLO systems are mostly tabletop devices, limiting their accessibility and utility in screening applications. Moreover, most existing SLO systems use raster scan patterns, which are both inefficient and lead to undesired subject gaze drift when used with visible or pseudo-visible illumination. Non-raster scan patterns, especially spiral scanning as described herein, promise advantages in both scan efficiency and reduced subject eye motion. In this work, we introduce a novel "hybrid spiral" scan pattern and the associated hardware design and real-time image reconstruction techniques necessary for its implementation in an SLO system. Building upon this core hybrid spiral scanning SLO (HSS-SLO) technology, we go on to present a complete handheld HSS-SLO system, featuring a fiber-coupled portable patient interface which leverages a dual-clad fiber (DCF) to form a single-path optical topology, thus ensuring mechanically robust co-alignment of illumination and collection apertures, a necessity for a handheld system. The feasibility of HSS-SLO for handheld, in vivo imaging is demonstrated by imaging eight human volunteers.

Duke Scholars

Published In

Biomed Opt Express

DOI

ISSN

2156-7085

Publication Date

October 1, 2023

Volume

14

Issue

10

Start / End Page

5162 / 5181

Location

United States

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4003 Biomedical engineering
  • 3212 Ophthalmology and optometry
  • 0912 Materials Engineering
  • 0205 Optical Physics
 

Citation

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Wei, F., Hagan, K., Viehland, C., Tao, Y. K., Kuo, A. N., Izatt, J. A., & Dhalla, A.-H. (2023). Hybrid spiral scanning in a double-clad fiber-based handheld confocal scanning light ophthalmoscope. Biomed Opt Express, 14(10), 5162–5181. https://doi.org/10.1364/BOE.500608
Wei, Franklin, Kristen Hagan, Christian Viehland, Yuankai K. Tao, Anthony N. Kuo, Joseph A. Izatt, and Al-Hafeez Dhalla. “Hybrid spiral scanning in a double-clad fiber-based handheld confocal scanning light ophthalmoscope.Biomed Opt Express 14, no. 10 (October 1, 2023): 5162–81. https://doi.org/10.1364/BOE.500608.
Wei F, Hagan K, Viehland C, Tao YK, Kuo AN, Izatt JA, et al. Hybrid spiral scanning in a double-clad fiber-based handheld confocal scanning light ophthalmoscope. Biomed Opt Express. 2023 Oct 1;14(10):5162–81.
Wei, Franklin, et al. “Hybrid spiral scanning in a double-clad fiber-based handheld confocal scanning light ophthalmoscope.Biomed Opt Express, vol. 14, no. 10, Oct. 2023, pp. 5162–81. Pubmed, doi:10.1364/BOE.500608.
Wei F, Hagan K, Viehland C, Tao YK, Kuo AN, Izatt JA, Dhalla A-H. Hybrid spiral scanning in a double-clad fiber-based handheld confocal scanning light ophthalmoscope. Biomed Opt Express. 2023 Oct 1;14(10):5162–5181.
Journal cover image

Published In

Biomed Opt Express

DOI

ISSN

2156-7085

Publication Date

October 1, 2023

Volume

14

Issue

10

Start / End Page

5162 / 5181

Location

United States

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4003 Biomedical engineering
  • 3212 Ophthalmology and optometry
  • 0912 Materials Engineering
  • 0205 Optical Physics