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Gene Delivery From Granular Scaffolds for Tunable Biologics Manufacturing.

Publication ,  Journal Article
Kurt, E; Devlin, G; Asokan, A; Segura, T
Published in: Small (Weinheim an der Bergstrasse, Germany)
March 2024

The understanding of the molecular basis for disease has generated a myriad of therapeutic biologics, including therapeutic proteins, antibodies, and viruses. However, the promise that biologics can resolve currently incurable diseases hinges in their manufacturability. These therapeutics require that their genetic material be introduced to mammalian cells such that the cell machinery can manufacture the biological components. These are then purified, validated, and packaged. Most manufacturing uses batch processes that collect the biologic a few days following genetic modification, due to toxicity or difficulty in separating product from cells in a continuous operation, limiting the amount of biologic that can be produced and resulting in yearlong backlogs. Here, a scaffold-based approach for continuous biologic manufacturing is presented, with sustained production of active antibodies and viruses for 30 days. The use of scaffold-based biologic production enabled perfusion-based bioreactors to be used, which can be incorporated into a fully continuous process.

Duke Scholars

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Published In

Small (Weinheim an der Bergstrasse, Germany)

DOI

EISSN

1613-6829

ISSN

1613-6810

Publication Date

March 2024

Start / End Page

e2309911

Related Subject Headings

  • Nanoscience & Nanotechnology
 

Citation

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Kurt, E., Devlin, G., Asokan, A., & Segura, T. (2024). Gene Delivery From Granular Scaffolds for Tunable Biologics Manufacturing. Small (Weinheim an Der Bergstrasse, Germany), e2309911. https://doi.org/10.1002/smll.202309911
Kurt, Evan, Garth Devlin, Aravind Asokan, and Tatiana Segura. “Gene Delivery From Granular Scaffolds for Tunable Biologics Manufacturing.Small (Weinheim an Der Bergstrasse, Germany), March 2024, e2309911. https://doi.org/10.1002/smll.202309911.
Kurt E, Devlin G, Asokan A, Segura T. Gene Delivery From Granular Scaffolds for Tunable Biologics Manufacturing. Small (Weinheim an der Bergstrasse, Germany). 2024 Mar;e2309911.
Kurt, Evan, et al. “Gene Delivery From Granular Scaffolds for Tunable Biologics Manufacturing.Small (Weinheim an Der Bergstrasse, Germany), Mar. 2024, p. e2309911. Epmc, doi:10.1002/smll.202309911.
Kurt E, Devlin G, Asokan A, Segura T. Gene Delivery From Granular Scaffolds for Tunable Biologics Manufacturing. Small (Weinheim an der Bergstrasse, Germany). 2024 Mar;e2309911.
Journal cover image

Published In

Small (Weinheim an der Bergstrasse, Germany)

DOI

EISSN

1613-6829

ISSN

1613-6810

Publication Date

March 2024

Start / End Page

e2309911

Related Subject Headings

  • Nanoscience & Nanotechnology