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Nutrition assessment and MASH severity in children using the Healthy Eating Index.

Publication ,  Journal Article
Jain, AK; Buchannan, P; Yates, KP; Belt, P; Schwimmer, JB; Rosenthal, P; Murray, KF; Molleston, JP; Scheimann, A; Xanthakos, SA; Behling, CA ...
Published in: Hepatol Commun
December 1, 2023

BACKGROUND: Pediatric metabolic-associated fatty liver disease (MAFLD) is a global health problem, with lifestyle modification as its major therapeutic strategy. Rigorous characterization of dietary content on MAFLD in children is lacking. We hypothesized an objectively measured healthier diet would positively modulate MAFLD. METHODS: Diet was assessed using the Nutrition Data System for Research in children enrolled from 10 tertiary clinical centers to determine the Healthy Eating Index (HEI, 0-100) and individual food components. RESULTS: In all, 119 children were included (13.3 ± 2.7 y), 80 (67%) male, 67 (18%) White, and 90 (76%) Hispanic, with an average body mass index Z-score of 2.2 ± 0.5. Diet was classified as low HEI < 47.94 (n = 39), mid HEI ≥ 47.94 and < 58.89 (n = 41), or high HEI ≥ 58.89 (n=39). Children with high HEI (healthier diet) had lower body weight (p = 0.005) and more favorable lipids. Mean serum triglycerides for low, mid, and high HEI were 163, 148, and 120 mg/dL, respectively; p = 0.04 mid versus high, p = 0.01 low versus high. Mean HDL was 38, 41 and 43 mg/dL; p = 0.02 low vs high. Less severe steatosis was noted with added sugar ≤ 10% of calories (p = 0.03). Higher lobular inflammation is associated with a higher percentage of calories from fat (OR (95% CI) = 0.95 (0.91-1.00), p = 0.04). CONCLUSIONS: In children with MAFLD, high HEI is associated with lower body weight and more favorable lipids, while added sugar and fat intake has individual histologic features. Differential consumption of major dietary components may modify both metabolic risk factors and histologic liver injury, highlighting the importance of objective diet assessments in children with MAFLD.

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Published In

Hepatol Commun

DOI

EISSN

2471-254X

Publication Date

December 1, 2023

Volume

7

Issue

12

Location

United States

Related Subject Headings

  • Sugars
  • Nutrition Assessment
  • Male
  • Lipids
  • Humans
  • Female
  • Diet, Healthy
  • Child
  • Body Weight
  • 3202 Clinical sciences
 

Citation

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Jain, A. K., Buchannan, P., Yates, K. P., Belt, P., Schwimmer, J. B., Rosenthal, P., … Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), . (2023). Nutrition assessment and MASH severity in children using the Healthy Eating Index. Hepatol Commun, 7(12). https://doi.org/10.1097/HC9.0000000000000320
Jain, Ajay Kumar, Paula Buchannan, Katherine P. Yates, Patricia Belt, Jeffrey B. Schwimmer, Philip Rosenthal, Karen F. Murray, et al. “Nutrition assessment and MASH severity in children using the Healthy Eating Index.Hepatol Commun 7, no. 12 (December 1, 2023). https://doi.org/10.1097/HC9.0000000000000320.
Jain AK, Buchannan P, Yates KP, Belt P, Schwimmer JB, Rosenthal P, et al. Nutrition assessment and MASH severity in children using the Healthy Eating Index. Hepatol Commun. 2023 Dec 1;7(12).
Jain, Ajay Kumar, et al. “Nutrition assessment and MASH severity in children using the Healthy Eating Index.Hepatol Commun, vol. 7, no. 12, Dec. 2023. Pubmed, doi:10.1097/HC9.0000000000000320.
Jain AK, Buchannan P, Yates KP, Belt P, Schwimmer JB, Rosenthal P, Murray KF, Molleston JP, Scheimann A, Xanthakos SA, Behling CA, Hertel P, Nilson J, Neuschwander-Tetri BA, Tonascia J, Vos MB, Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN). Nutrition assessment and MASH severity in children using the Healthy Eating Index. Hepatol Commun. 2023 Dec 1;7(12).

Published In

Hepatol Commun

DOI

EISSN

2471-254X

Publication Date

December 1, 2023

Volume

7

Issue

12

Location

United States

Related Subject Headings

  • Sugars
  • Nutrition Assessment
  • Male
  • Lipids
  • Humans
  • Female
  • Diet, Healthy
  • Child
  • Body Weight
  • 3202 Clinical sciences