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Immune Checkpoint Inhibitors in Geriatric Oncology.

Publication ,  Journal Article
Cook, SL; Al Amin, M; Bari, S; Poonnen, PJ; Khasraw, M; Johnson, MO
Published in: Curr Oncol Rep
May 2024

PURPOSE OF REVIEW: This manuscript will update prior reviews of immune checkpoint inhibitors (ICIs) in light of basic science, translational, and clinical discoveries in the field of cancer immunology and aging. RECENT FINDINGS: ICIs have led to significant advancements in the treatment of cancer. Landmark trials of ICIs have cited the efficacy and toxicity experienced by older patients, but most trials are not specifically designed to address outcomes in older patients. Underlying mechanisms of aging, like cellular senescence, affect the immune system and may ultimately alter the host's response to ICIs. Validated tools are currently used to identify older adults who may be at greater risk of developing complications from their cancer treatment. We review changes in the aging immune system that may alter responses to ICIs, report outcomes and toxicities in older adults from recent ICI clinical trials, and discuss clinical tools specific to older patients with cancer.

Duke Scholars

Published In

Curr Oncol Rep

DOI

EISSN

1534-6269

Publication Date

May 2024

Volume

26

Issue

5

Start / End Page

562 / 572

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Neoplasms
  • Medical Oncology
  • Immunotherapy
  • Immune Checkpoint Inhibitors
  • Humans
  • Geriatrics
  • Aging
  • Aged
  • 3211 Oncology and carcinogenesis
 

Citation

APA
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Cook, S. L., Al Amin, M., Bari, S., Poonnen, P. J., Khasraw, M., & Johnson, M. O. (2024). Immune Checkpoint Inhibitors in Geriatric Oncology. Curr Oncol Rep, 26(5), 562–572. https://doi.org/10.1007/s11912-024-01528-3
Cook, Sarah L., Md Al Amin, Shahla Bari, Pradeep J. Poonnen, Mustafa Khasraw, and Margaret O. Johnson. “Immune Checkpoint Inhibitors in Geriatric Oncology.Curr Oncol Rep 26, no. 5 (May 2024): 562–72. https://doi.org/10.1007/s11912-024-01528-3.
Cook SL, Al Amin M, Bari S, Poonnen PJ, Khasraw M, Johnson MO. Immune Checkpoint Inhibitors in Geriatric Oncology. Curr Oncol Rep. 2024 May;26(5):562–72.
Cook, Sarah L., et al. “Immune Checkpoint Inhibitors in Geriatric Oncology.Curr Oncol Rep, vol. 26, no. 5, May 2024, pp. 562–72. Pubmed, doi:10.1007/s11912-024-01528-3.
Cook SL, Al Amin M, Bari S, Poonnen PJ, Khasraw M, Johnson MO. Immune Checkpoint Inhibitors in Geriatric Oncology. Curr Oncol Rep. 2024 May;26(5):562–572.
Journal cover image

Published In

Curr Oncol Rep

DOI

EISSN

1534-6269

Publication Date

May 2024

Volume

26

Issue

5

Start / End Page

562 / 572

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Neoplasms
  • Medical Oncology
  • Immunotherapy
  • Immune Checkpoint Inhibitors
  • Humans
  • Geriatrics
  • Aging
  • Aged
  • 3211 Oncology and carcinogenesis