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Monitoring human exposure to four parabens and triclosan: comparing silicone wristbands with spot urine samples as predictors of internal dose.

Publication ,  Journal Article
Levasseur, JL; Hoffman, K; Zhang, S; Cooper, EM; Stapleton, HM
Published in: Journal of exposure science & environmental epidemiology
May 2024

People are exposed to a variety of chemicals each day as a result of their personal care product (PCP) use.This study was designed to determine if silicone wristbands provide a quantitative estimate of internal dose for phenols commonly associated with PCPs, with a focus on triclosan and four parabens: methyl-, ethyl-, propyl-, and butylparaben. Uptake of these compounds into wristbands and correlations with internal dose were assessed.Ten adults from central North Carolina wore five silicone wristbands, with one wristband removed each day for 5 days. Each participant provided a 24 h urine sample and a random spot urine sample each day, in which paraben and triclosan metabolites were evaluated.All parabens and triclosan were detected frequently in wristbands and, except for butylparaben, in urine samples. Wristband and spot urine concentrations of parabens and triclosan were both compared to a measurement of internal dose (i.e., the total metabolite mass excreted over 5 days as a measurement of internal dose).The two most hydrophobic compounds investigated, butylparaben and triclosan, displayed significant linear uptake in wristbands over 5 days, whereas concentrations of methyl- and ethylparaben displayed a steady state concentration. In general, wristbands and spot urine samples were similarly correlated to internal dose for frequently detected parabens and triclosan.  However, wristbands have additional advantages including higher detection rates and reduced participant burden that may make them more suitable tools for assessing exposure to PCPs.

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Published In

Journal of exposure science & environmental epidemiology

DOI

EISSN

1559-064X

ISSN

1559-0631

Publication Date

May 2024

Related Subject Headings

  • Epidemiology
  • 4206 Public health
  • 4202 Epidemiology
  • 11 Medical and Health Sciences
  • 05 Environmental Sciences
  • 03 Chemical Sciences
 

Citation

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Levasseur, J. L., Hoffman, K., Zhang, S., Cooper, E. M., & Stapleton, H. M. (2024). Monitoring human exposure to four parabens and triclosan: comparing silicone wristbands with spot urine samples as predictors of internal dose. Journal of Exposure Science & Environmental Epidemiology. https://doi.org/10.1038/s41370-024-00663-0
Levasseur, Jessica L., Kate Hoffman, Sharon Zhang, Ellen M. Cooper, and Heather M. Stapleton. “Monitoring human exposure to four parabens and triclosan: comparing silicone wristbands with spot urine samples as predictors of internal dose.Journal of Exposure Science & Environmental Epidemiology, May 2024. https://doi.org/10.1038/s41370-024-00663-0.
Levasseur JL, Hoffman K, Zhang S, Cooper EM, Stapleton HM. Monitoring human exposure to four parabens and triclosan: comparing silicone wristbands with spot urine samples as predictors of internal dose. Journal of exposure science & environmental epidemiology. 2024 May;
Levasseur, Jessica L., et al. “Monitoring human exposure to four parabens and triclosan: comparing silicone wristbands with spot urine samples as predictors of internal dose.Journal of Exposure Science & Environmental Epidemiology, May 2024. Epmc, doi:10.1038/s41370-024-00663-0.
Levasseur JL, Hoffman K, Zhang S, Cooper EM, Stapleton HM. Monitoring human exposure to four parabens and triclosan: comparing silicone wristbands with spot urine samples as predictors of internal dose. Journal of exposure science & environmental epidemiology. 2024 May;

Published In

Journal of exposure science & environmental epidemiology

DOI

EISSN

1559-064X

ISSN

1559-0631

Publication Date

May 2024

Related Subject Headings

  • Epidemiology
  • 4206 Public health
  • 4202 Epidemiology
  • 11 Medical and Health Sciences
  • 05 Environmental Sciences
  • 03 Chemical Sciences