Skip to main content

Molecular Subtypes of High-Grade Serous Ovarian Cancer across Racial Groups and Gene Expression Platforms.

Publication ,  Journal Article
Davidson, NR; Barnard, ME; Hippen, AA; Campbell, A; Johnson, CE; Way, GP; Dalley, BK; Berchuck, A; Salas, LA; Peres, LC; Marks, JR; Greene, CS ...
Published in: Cancer Epidemiol Biomarkers Prev
August 1, 2024

BACKGROUND: High-grade serous carcinoma (HGSC) gene expression subtypes are associated with differential survival. We characterized HGSC gene expression in Black individuals and considered whether gene expression differences by self-identified race may contribute to poorer HGSC survival among Black versus White individuals. METHODS: We included newly generated RNA sequencing data from Black and White individuals and array-based genotyping data from four existing studies of White and Japanese individuals. We used K-means clustering, a method with no predefined number of clusters or dataset-specific features, to assign subtypes. Cluster- and dataset-specific gene expression patterns were summarized by moderated t-scores. We compared cluster-specific gene expression patterns across datasets by calculating the correlation between the summarized vectors of moderated t-scores. After mapping to The Cancer Genome Atlas-derived HGSC subtypes, we used Cox proportional hazards models to estimate subtype-specific survival by dataset. RESULTS: Cluster-specific gene expression was similar across gene expression platforms and racial groups. Comparing the Black population with the White and Japanese populations, the immunoreactive subtype was more common (39% vs. 23%-28%) and the differentiated subtype was less common (7% vs. 22%-31%). Patterns of subtype-specific survival were similar between the Black and White populations with RNA sequencing data; compared with mesenchymal cases, the risk of death was similar for proliferative and differentiated cases and suggestively lower for immunoreactive cases [Black population HR = 0.79 (0.55, 1.13); White population HR = 0.86 (0.62, 1.19)]. CONCLUSIONS: Although the prevalence of HGSC subtypes varied by race, subtype-specific survival was similar. IMPACT: HGSC subtypes can be consistently assigned across platforms and self-identified racial groups.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

August 1, 2024

Volume

33

Issue

8

Start / End Page

1114 / 1125

Location

United States

Related Subject Headings

  • White
  • Ovarian Neoplasms
  • Neoplasm Grading
  • Middle Aged
  • Humans
  • Female
  • Epidemiology
  • Cystadenocarcinoma, Serous
  • Black or African American
  • Aged
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Davidson, N. R., Barnard, M. E., Hippen, A. A., Campbell, A., Johnson, C. E., Way, G. P., … Doherty, J. A. (2024). Molecular Subtypes of High-Grade Serous Ovarian Cancer across Racial Groups and Gene Expression Platforms. Cancer Epidemiol Biomarkers Prev, 33(8), 1114–1125. https://doi.org/10.1158/1055-9965.EPI-24-0113
Davidson, Natalie R., Mollie E. Barnard, Ariel A. Hippen, Amy Campbell, Courtney E. Johnson, Gregory P. Way, Brian K. Dalley, et al. “Molecular Subtypes of High-Grade Serous Ovarian Cancer across Racial Groups and Gene Expression Platforms.Cancer Epidemiol Biomarkers Prev 33, no. 8 (August 1, 2024): 1114–25. https://doi.org/10.1158/1055-9965.EPI-24-0113.
Davidson NR, Barnard ME, Hippen AA, Campbell A, Johnson CE, Way GP, et al. Molecular Subtypes of High-Grade Serous Ovarian Cancer across Racial Groups and Gene Expression Platforms. Cancer Epidemiol Biomarkers Prev. 2024 Aug 1;33(8):1114–25.
Davidson, Natalie R., et al. “Molecular Subtypes of High-Grade Serous Ovarian Cancer across Racial Groups and Gene Expression Platforms.Cancer Epidemiol Biomarkers Prev, vol. 33, no. 8, Aug. 2024, pp. 1114–25. Pubmed, doi:10.1158/1055-9965.EPI-24-0113.
Davidson NR, Barnard ME, Hippen AA, Campbell A, Johnson CE, Way GP, Dalley BK, Berchuck A, Salas LA, Peres LC, Marks JR, Schildkraut JM, Greene CS, Doherty JA. Molecular Subtypes of High-Grade Serous Ovarian Cancer across Racial Groups and Gene Expression Platforms. Cancer Epidemiol Biomarkers Prev. 2024 Aug 1;33(8):1114–1125.

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

August 1, 2024

Volume

33

Issue

8

Start / End Page

1114 / 1125

Location

United States

Related Subject Headings

  • White
  • Ovarian Neoplasms
  • Neoplasm Grading
  • Middle Aged
  • Humans
  • Female
  • Epidemiology
  • Cystadenocarcinoma, Serous
  • Black or African American
  • Aged