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Association Between the Need to Change Initial Antifungal Therapy and Treatment Costs in Patients With Invasive Aspergillosis.

Publication ,  Journal Article
Alexander, BD; Johnson, M; Bresnik, M; Anupindi, VR; Pizzicato, L; DeKoven, M; Lovelace, B; Coleman, CI
Published in: Open Forum Infect Dis
January 2025

BACKGROUND: Early antifungal initiation in invasive aspergillosis (IA) is recommended. Changing antifungals occurs for a myriad of reasons but associated costs are unclear. METHODS: US claims data for adults admitted for IA were identified from 10/1/2015 to 11/30/2022. Patients were stratified by those who did and did not change antifungal therapy. Adjusted all-cause healthcare utilization and costs/patient during index hospitalization and at 1, 6, and 12-months after the index date between the cohorts that did and did not change antifungal therapy were compared. RESULTS: Among 1,192 IA patients, 707 (59.3%) changed their initial antifungal therapy over follow-up. The index hospital length of stay was longer (Δ = 6 days, P < .001) and costs were higher (Δ = $65,149, P < .001) in the change vs. no change cohort. Median 1, 6, and 12-months all-cause costs were higher in patients changing antifungal therapy vs. not (Δ = $90,938-$192,953). CONCLUSIONS: Changing antifungals was associated with longer hospital stays and costs and higher all-cause costs over 12-months.

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Published In

Open Forum Infect Dis

DOI

ISSN

2328-8957

Publication Date

January 2025

Volume

12

Issue

1

Start / End Page

ofae747

Location

United States

Related Subject Headings

  • 3207 Medical microbiology
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Alexander, B. D., Johnson, M., Bresnik, M., Anupindi, V. R., Pizzicato, L., DeKoven, M., … Coleman, C. I. (2025). Association Between the Need to Change Initial Antifungal Therapy and Treatment Costs in Patients With Invasive Aspergillosis. Open Forum Infect Dis, 12(1), ofae747. https://doi.org/10.1093/ofid/ofae747
Alexander, Barbara D., Melissa Johnson, Mark Bresnik, Vamshi Ruthwik Anupindi, Lia Pizzicato, Mitchell DeKoven, Belinda Lovelace, and Craig I. Coleman. “Association Between the Need to Change Initial Antifungal Therapy and Treatment Costs in Patients With Invasive Aspergillosis.Open Forum Infect Dis 12, no. 1 (January 2025): ofae747. https://doi.org/10.1093/ofid/ofae747.
Alexander BD, Johnson M, Bresnik M, Anupindi VR, Pizzicato L, DeKoven M, et al. Association Between the Need to Change Initial Antifungal Therapy and Treatment Costs in Patients With Invasive Aspergillosis. Open Forum Infect Dis. 2025 Jan;12(1):ofae747.
Alexander, Barbara D., et al. “Association Between the Need to Change Initial Antifungal Therapy and Treatment Costs in Patients With Invasive Aspergillosis.Open Forum Infect Dis, vol. 12, no. 1, Jan. 2025, p. ofae747. Pubmed, doi:10.1093/ofid/ofae747.
Alexander BD, Johnson M, Bresnik M, Anupindi VR, Pizzicato L, DeKoven M, Lovelace B, Coleman CI. Association Between the Need to Change Initial Antifungal Therapy and Treatment Costs in Patients With Invasive Aspergillosis. Open Forum Infect Dis. 2025 Jan;12(1):ofae747.
Journal cover image

Published In

Open Forum Infect Dis

DOI

ISSN

2328-8957

Publication Date

January 2025

Volume

12

Issue

1

Start / End Page

ofae747

Location

United States

Related Subject Headings

  • 3207 Medical microbiology
  • 3202 Clinical sciences