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Investigating the impact of sickle cell disease on red blood cell transport in complex capillary networks.

Publication ,  Conference
Wu, R; Kabir, MS; Truskey, GA; Randles, A
Published in: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
July 2024

Sickle cell disease encompasses a variety of inherited red blood cell (RBC) disorders characterized by abnormal thrombosis, microvascular occlusion, end-organ ischemia, and early mortality. Understanding how sickle RBCs drive abnormal blood flow and stress on the endothelial wall is essential to predict and prevent blockages in blood circulation. While there are studies comparing blood flow velocity and pressure via computational fluid dynamics simulations, there are still open questions about how sickle cells interact with plasma in a complex capillary network. In order to quantify the hemodynamic differences between normal and sickle cells, we introduced a sickle cell RBC model to massively parallel fluid-structure interaction software HARVEY. Notably, sickle RBCs exhibit increased margination, aggregation at the inner curvature, slower fluid velocity, higher pressure, and greater wall shear stress at standard hematocrit levels. This computational model facilitates detailed cellular modeling for hemodynamic simulations in complex capillary networks, offering predictive insight into blockage and potential vessel ruptures in patients with sickle cell disease.

Duke Scholars

Published In

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

DOI

EISSN

2694-0604

ISSN

2375-7477

Publication Date

July 2024

Volume

2024

Start / End Page

1 / 4

Related Subject Headings

  • Models, Cardiovascular
  • Humans
  • Hemodynamics
  • Erythrocytes
  • Computer Simulation
  • Capillaries
  • Anemia, Sickle Cell
 

Citation

APA
Chicago
ICMJE
MLA
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Wu, R., Kabir, M. S., Truskey, G. A., & Randles, A. (2024). Investigating the impact of sickle cell disease on red blood cell transport in complex capillary networks. In Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference (Vol. 2024, pp. 1–4). https://doi.org/10.1109/embc53108.2024.10781578
Wu, Runxin, Mohammed Shihab Kabir, George A. Truskey, and Amanda Randles. “Investigating the impact of sickle cell disease on red blood cell transport in complex capillary networks.” In Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2024:1–4, 2024. https://doi.org/10.1109/embc53108.2024.10781578.
Wu R, Kabir MS, Truskey GA, Randles A. Investigating the impact of sickle cell disease on red blood cell transport in complex capillary networks. In: Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Annual International Conference. 2024. p. 1–4.
Wu, Runxin, et al. “Investigating the impact of sickle cell disease on red blood cell transport in complex capillary networks.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, vol. 2024, 2024, pp. 1–4. Epmc, doi:10.1109/embc53108.2024.10781578.
Wu R, Kabir MS, Truskey GA, Randles A. Investigating the impact of sickle cell disease on red blood cell transport in complex capillary networks. Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Annual International Conference. 2024. p. 1–4.

Published In

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

DOI

EISSN

2694-0604

ISSN

2375-7477

Publication Date

July 2024

Volume

2024

Start / End Page

1 / 4

Related Subject Headings

  • Models, Cardiovascular
  • Humans
  • Hemodynamics
  • Erythrocytes
  • Computer Simulation
  • Capillaries
  • Anemia, Sickle Cell