Skip to main content

Islet hormones at the intersection of glucose and amino acid metabolism.

Publication ,  Journal Article
White, PJ; Wewer Albrechtsen, NJ; Campbell, JE
Published in: Nat Rev Endocrinol
March 7, 2025

The pancreatic islets of Langerhans are central to fine-tuning metabolism to ensure metabolic homeostasis during the transition between fasting and feeding. Insulin and glucagon, the principal hormones generated and secreted by islets, exert powerful control in various metabolic tissues to drive nutrient uptake, storage and metabolism. Their canonical actions on glycaemia have positioned these hormones in opposition, however, their metabolic actions extend beyond controlling blood levels of glucose. Indeed, these islet hormones are just as influential in regulating lipid and amino acid metabolism and it is becoming clear that many of these actions involve an interplay between insulin and glucagon, which is contrary to the dogmatic view that these hormones are antagonistic in nature. Finally, we postulate that examining the effects of islet hormones on the metabolism of individual metabolites is overly simplistic. Here, we discuss the actions of each islet hormone alone and in combination with the others in regulating glucose and amino acid metabolism and explore how these signalling networks are closely linked and strongly influence one another.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nat Rev Endocrinol

DOI

EISSN

1759-5037

Publication Date

March 7, 2025

Location

England

Related Subject Headings

  • Endocrinology & Metabolism
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
White, P. J., Wewer Albrechtsen, N. J., & Campbell, J. E. (2025). Islet hormones at the intersection of glucose and amino acid metabolism. Nat Rev Endocrinol. https://doi.org/10.1038/s41574-025-01100-4
White, Phillip J., Nicolai J. Wewer Albrechtsen, and Jonathan E. Campbell. “Islet hormones at the intersection of glucose and amino acid metabolism.Nat Rev Endocrinol, March 7, 2025. https://doi.org/10.1038/s41574-025-01100-4.
White PJ, Wewer Albrechtsen NJ, Campbell JE. Islet hormones at the intersection of glucose and amino acid metabolism. Nat Rev Endocrinol. 2025 Mar 7;
White, Phillip J., et al. “Islet hormones at the intersection of glucose and amino acid metabolism.Nat Rev Endocrinol, Mar. 2025. Pubmed, doi:10.1038/s41574-025-01100-4.
White PJ, Wewer Albrechtsen NJ, Campbell JE. Islet hormones at the intersection of glucose and amino acid metabolism. Nat Rev Endocrinol. 2025 Mar 7;

Published In

Nat Rev Endocrinol

DOI

EISSN

1759-5037

Publication Date

March 7, 2025

Location

England

Related Subject Headings

  • Endocrinology & Metabolism
  • 3202 Clinical sciences