Frailty assessment and candidate optimization before cardiothoracic transplantation.
Publication
, Journal Article
Premachandra, A; Klapper, J; Messika, J; Gaillard, M; Kloeckner, M; Ghadimi, K; Reffienna, M; Ingle, K; Magudia, K; Bottiger, B
Published in: JHLT Open
May 2026
Frailty is an important syndrome in an aging thoracic transplant population, particularly in the context of end-stage cardiopulmonary disease. In this review, we discuss the core problem of lack of physiologic reserve in these patients and its relationship to perioperative outcomes, how to define and measure frailty in the context of heart and lung transplant and identify interventions to treat contributors to this clinical syndrome. We highlight the critical need in the transplant community to identify and treat these conditions prior to their transplantation and to prevent comorbidity and mortality.
Duke Scholars
Published In
JHLT Open
DOI
EISSN
2950-1334
Publication Date
May 2026
Volume
12
Start / End Page
100492
Location
United States
Citation
APA
Chicago
ICMJE
MLA
NLM
Premachandra, A., Klapper, J., Messika, J., Gaillard, M., Kloeckner, M., Ghadimi, K., … Bottiger, B. (2026). Frailty assessment and candidate optimization before cardiothoracic transplantation. JHLT Open, 12, 100492. https://doi.org/10.1016/j.jhlto.2026.100492
Premachandra, Antoine, Jacob Klapper, Jonathan Messika, Maira Gaillard, Martin Kloeckner, Kamrouz Ghadimi, Matthieu Reffienna, Krista Ingle, Kirti Magudia, and Brandi Bottiger. “Frailty assessment and candidate optimization before cardiothoracic transplantation.” JHLT Open 12 (May 2026): 100492. https://doi.org/10.1016/j.jhlto.2026.100492.
Premachandra A, Klapper J, Messika J, Gaillard M, Kloeckner M, Ghadimi K, et al. Frailty assessment and candidate optimization before cardiothoracic transplantation. JHLT Open. 2026 May;12:100492.
Premachandra, Antoine, et al. “Frailty assessment and candidate optimization before cardiothoracic transplantation.” JHLT Open, vol. 12, May 2026, p. 100492. Pubmed, doi:10.1016/j.jhlto.2026.100492.
Premachandra A, Klapper J, Messika J, Gaillard M, Kloeckner M, Ghadimi K, Reffienna M, Ingle K, Magudia K, Bottiger B. Frailty assessment and candidate optimization before cardiothoracic transplantation. JHLT Open. 2026 May;12:100492.
Published In
JHLT Open
DOI
EISSN
2950-1334
Publication Date
May 2026
Volume
12
Start / End Page
100492
Location
United States