Supplementary Figure S1 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy

<p>Supplementary Fig. S1. A) UMAP visualization of scRNA-seq data colored by patient identity. B) UMAP visualization of scRNA-seq data colored by timepoint (T1 = pre-abemaciclib and ET, T2 = post-abemaciclib and ET). C) Dot plot of proportion of copy number variation (CNV) in indicated chromosome per cluster. Size represents the percent of cells within each cluster in which a CNV was detected, and color represents the mean proportion of genes per cell with any CNV for the chromosome. D) Relative proportions of broad cell types per patient per timepoint per metastasis site.</p>

Duke Scholars

Author Binita Chakraborty  

Author Kent James Weinhold Surgery, Surgical Sciences

Author Donald Patrick McDonnell Pharmacology & Cancer Biology

Author Ching-yi Chang Pharmacology & Cancer Biology