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Amino acid preferences for specific locations at the ends of alpha helices.

Publication ,  Journal Article
Richardson, JS; Richardson, DC
Published in: Science
June 17, 1988

A definition based on alpha-carbon positions and a sample of 215 alpha helices from 45 different globular protein structures were used to tabulate amino acid preferences for 16 individual positions relative to the helix ends. The interface residue, which is half in and half out of the helix, is called the N-cap or C-cap, whichever is appropriate. The results confirm earlier observations, such as asymmetrical charge distributions in the first and last helical turn, but several new, sharp preferences are found as well. The most striking of these are a 3.5:1 preference for Asn at the N-cap position, and a preference of 2.6:1 for Pro at N-cap + 1. The C-cap position is overwhelmingly dominated by Gly, which ends 34 percent of the helices. Hydrophobic residues peak at positions N-cap + 4 and C-cap - 4.

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Published In

Science

DOI

ISSN

0036-8075

Publication Date

June 17, 1988

Volume

240

Issue

4859

Start / End Page

1648 / 1652

Location

United States

Related Subject Headings

  • Protein Conformation
  • Proline
  • Hydrogen Bonding
  • General Science & Technology
  • Asparagine
  • Amino Acids
  • Amino Acid Sequence
 

Citation

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Richardson, J. S., & Richardson, D. C. (1988). Amino acid preferences for specific locations at the ends of alpha helices. Science, 240(4859), 1648–1652. https://doi.org/10.1126/science.3381086
Richardson, J. S., and D. C. Richardson. “Amino acid preferences for specific locations at the ends of alpha helices.Science 240, no. 4859 (June 17, 1988): 1648–52. https://doi.org/10.1126/science.3381086.
Richardson JS, Richardson DC. Amino acid preferences for specific locations at the ends of alpha helices. Science. 1988 Jun 17;240(4859):1648–52.
Richardson, J. S., and D. C. Richardson. “Amino acid preferences for specific locations at the ends of alpha helices.Science, vol. 240, no. 4859, June 1988, pp. 1648–52. Pubmed, doi:10.1126/science.3381086.
Richardson JS, Richardson DC. Amino acid preferences for specific locations at the ends of alpha helices. Science. 1988 Jun 17;240(4859):1648–1652.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

June 17, 1988

Volume

240

Issue

4859

Start / End Page

1648 / 1652

Location

United States

Related Subject Headings

  • Protein Conformation
  • Proline
  • Hydrogen Bonding
  • General Science & Technology
  • Asparagine
  • Amino Acids
  • Amino Acid Sequence