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Lymph-node bacilliform bodies resembling those of Whipple's disease in a patient without intestinal involvement.

Publication ,  Journal Article
Mansbach, CM; Shelburne, JD; Stevens, RD; Dobbins, WO
Published in: Ann Intern Med
July 1978

A 38-year-old man developed symptoms of arthalgias and arthritis, lymphadenopathy, and weight loss. An axillary lymph-node biopsy was done in the diagnostic study; a periodic acid Schiff stain, done for evidence of fungal infection, showed periodic acid Schiff reagent-positive macrophages. Electron microscopy showed the typical morphologic features of the bacilliform bodies associated with Whipple's disease to be present in the macrophages of the lymph node. The patient had no intestinal symptoms. The absorption of a variety of substrates was found to be normal. Nine intestinal biopsies showed no organisms similar to those found in his lymph node. On tetracycline therapy, he symptomatically improved. The findings raise the question of the route of infection in Whipple's disease and point up the usefulness of periodic acid Schiff staining of lymph-node biopsies.

Duke Scholars

Published In

Ann Intern Med

DOI

ISSN

0003-4819

Publication Date

July 1978

Volume

89

Issue

1

Start / End Page

64 / 66

Location

United States

Related Subject Headings

  • Whipple Disease
  • Periodic Acid-Schiff Reaction
  • Male
  • Macrophages
  • Lymph Nodes
  • Intestine, Small
  • Humans
  • General & Internal Medicine
  • Biopsy
  • Adult
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mansbach, C. M., Shelburne, J. D., Stevens, R. D., & Dobbins, W. O. (1978). Lymph-node bacilliform bodies resembling those of Whipple's disease in a patient without intestinal involvement. Ann Intern Med, 89(1), 64–66. https://doi.org/10.7326/0003-4819-89-1-64
Mansbach, C. M., J. D. Shelburne, R. D. Stevens, and W. O. Dobbins. “Lymph-node bacilliform bodies resembling those of Whipple's disease in a patient without intestinal involvement.Ann Intern Med 89, no. 1 (July 1978): 64–66. https://doi.org/10.7326/0003-4819-89-1-64.
Mansbach CM, Shelburne JD, Stevens RD, Dobbins WO. Lymph-node bacilliform bodies resembling those of Whipple's disease in a patient without intestinal involvement. Ann Intern Med. 1978 Jul;89(1):64–6.
Mansbach, C. M., et al. “Lymph-node bacilliform bodies resembling those of Whipple's disease in a patient without intestinal involvement.Ann Intern Med, vol. 89, no. 1, July 1978, pp. 64–66. Pubmed, doi:10.7326/0003-4819-89-1-64.
Mansbach CM, Shelburne JD, Stevens RD, Dobbins WO. Lymph-node bacilliform bodies resembling those of Whipple's disease in a patient without intestinal involvement. Ann Intern Med. 1978 Jul;89(1):64–66.

Published In

Ann Intern Med

DOI

ISSN

0003-4819

Publication Date

July 1978

Volume

89

Issue

1

Start / End Page

64 / 66

Location

United States

Related Subject Headings

  • Whipple Disease
  • Periodic Acid-Schiff Reaction
  • Male
  • Macrophages
  • Lymph Nodes
  • Intestine, Small
  • Humans
  • General & Internal Medicine
  • Biopsy
  • Adult