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An auxotrophic pigmented Cryptococcus neoformans strain causing infection of the bone marrow.

Publication ,  Journal Article
Schiappa, D; Gueyikian, A; Kakar, S; Alspaugh, JA; Perfect, JR; Williamson, PR
Published in: Med Mycol
February 2002

Cryptococcosis, caused by an encapsulated fungus, Cryptococcus neoformans, has emerged as a life-threatening infection in HIV-positive individuals and other immunocompromised hosts. This report describes an unusual strain of C. neoformans isolated from an AIDS patient that developed pigment on Sabouraud's medium. The yeast was auxotrophic for adenine due to a deletion in the coding region of ADE2, and was complemented by introduction of a functional copy of the ADE2 gene from C. neoformans. The yeast had an unusual myelotropism that was clinically evident as a pancytopenia with displacement of bone marrow precursors by yeast cells, and it had an unusual spectrum of infection in the human host. This is the first description of a nutritional auxotroph of C. neoformans isolated from a patient.

Duke Scholars

Published In

Med Mycol

DOI

ISSN

1369-3786

Publication Date

February 2002

Volume

40

Issue

1

Start / End Page

1 / 5

Location

England

Related Subject Headings

  • Virulence
  • Molecular Sequence Data
  • Microbiology
  • Male
  • Humans
  • Cryptococcus neoformans
  • Cryptococcosis
  • Carboxy-Lyases
  • Bone Marrow
  • Amino Acid Sequence
 

Citation

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Schiappa, D., Gueyikian, A., Kakar, S., Alspaugh, J. A., Perfect, J. R., & Williamson, P. R. (2002). An auxotrophic pigmented Cryptococcus neoformans strain causing infection of the bone marrow. Med Mycol, 40(1), 1–5. https://doi.org/10.1080/mmy.40.1.1.5
Schiappa, D., A. Gueyikian, S. Kakar, J. A. Alspaugh, J. R. Perfect, and P. R. Williamson. “An auxotrophic pigmented Cryptococcus neoformans strain causing infection of the bone marrow.Med Mycol 40, no. 1 (February 2002): 1–5. https://doi.org/10.1080/mmy.40.1.1.5.
Schiappa D, Gueyikian A, Kakar S, Alspaugh JA, Perfect JR, Williamson PR. An auxotrophic pigmented Cryptococcus neoformans strain causing infection of the bone marrow. Med Mycol. 2002 Feb;40(1):1–5.
Schiappa, D., et al. “An auxotrophic pigmented Cryptococcus neoformans strain causing infection of the bone marrow.Med Mycol, vol. 40, no. 1, Feb. 2002, pp. 1–5. Pubmed, doi:10.1080/mmy.40.1.1.5.
Schiappa D, Gueyikian A, Kakar S, Alspaugh JA, Perfect JR, Williamson PR. An auxotrophic pigmented Cryptococcus neoformans strain causing infection of the bone marrow. Med Mycol. 2002 Feb;40(1):1–5.
Journal cover image

Published In

Med Mycol

DOI

ISSN

1369-3786

Publication Date

February 2002

Volume

40

Issue

1

Start / End Page

1 / 5

Location

England

Related Subject Headings

  • Virulence
  • Molecular Sequence Data
  • Microbiology
  • Male
  • Humans
  • Cryptococcus neoformans
  • Cryptococcosis
  • Carboxy-Lyases
  • Bone Marrow
  • Amino Acid Sequence