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TRPC3 channels confer cellular memory of recent neuromuscular activity.

Publication ,  Journal Article
Rosenberg, P; Hawkins, A; Stiber, J; Shelton, JM; Hutcheson, K; Bassel-Duby, R; Shin, DM; Yan, Z; Williams, RS
Published in: Proc Natl Acad Sci U S A
June 22, 2004
Published version (DOI) Link to item

Skeletal muscle adapts to different patterns of motor nerve activity by alterations in gene expression that match specialized properties of contraction, metabolism, and muscle mass to changing work demands (muscle plasticity). Calcineurin, a calcium/calmodulin-dependent, serine-threonine protein phosphatase, has been shown to control programs of gene expression in skeletal muscles, as in other cell types, through the transcription factor nuclear factor of activated T cells (NFAT). This study provides evidence that the function of NFAT as a transcriptional activator is regulated by neuromuscular stimulation in muscles of intact animals and that calcium influx from the transient receptor potential (TRPC3) channel is an important determinant of NFAT activity. Expression of TRPC3 channels in skeletal myocytes is up-regulated by neuromuscular activity in a calcineurin-dependent manner. These data suggest a mechanism for cellular memory in skeletal muscles whereby repeated bouts of contractile activity drive progressively greater remodeling events.

Duke Scholars

Paul Brian Rosenberg
Author Paul Brian Rosenberg Medicine, Cardiology
Jonathan Andrew Stiber
Author Jonathan Andrew Stiber Medicine, Cardiology

Published In

Proc Natl Acad Sci U S A

DOI

10.1073/pnas.0308179101

ISSN

0027-8424

Publication Date

June 22, 2004

Volume

101

Issue

25

Start / End Page

9387 / 9392

Location

United States

Related Subject Headings

  • Transcription Factors
  • TRPC Cation Channels
  • Promoter Regions, Genetic
  • Phosphoproteins
  • Nuclear Proteins
  • Neuromuscular Junction
  • NFATC Transcription Factors
  • Muscle, Skeletal
  • Muscle Proteins
  • Muscle Contraction
 

Citation

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Rosenberg, P., Hawkins, A., Stiber, J., Shelton, J. M., Hutcheson, K., Bassel-Duby, R., … Williams, R. S. (2004). TRPC3 channels confer cellular memory of recent neuromuscular activity. Proc Natl Acad Sci U S A, 101(25), 9387–9392. https://doi.org/10.1073/pnas.0308179101
Rosenberg, Paul, April Hawkins, Jonathan Stiber, John M. Shelton, Kelley Hutcheson, Rhonda Bassel-Duby, Dong Min Shin, Zhen Yan, and R Sanders Williams. “TRPC3 channels confer cellular memory of recent neuromuscular activity.” Proc Natl Acad Sci U S A 101, no. 25 (June 22, 2004): 9387–92. https://doi.org/10.1073/pnas.0308179101.
Rosenberg P, Hawkins A, Stiber J, Shelton JM, Hutcheson K, Bassel-Duby R, et al. TRPC3 channels confer cellular memory of recent neuromuscular activity. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9387–92.
Rosenberg, Paul, et al. “TRPC3 channels confer cellular memory of recent neuromuscular activity.” Proc Natl Acad Sci U S A, vol. 101, no. 25, June 2004, pp. 9387–92. Pubmed, doi:10.1073/pnas.0308179101.
Rosenberg P, Hawkins A, Stiber J, Shelton JM, Hutcheson K, Bassel-Duby R, Shin DM, Yan Z, Williams RS. TRPC3 channels confer cellular memory of recent neuromuscular activity. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9387–9392.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

10.1073/pnas.0308179101

ISSN

0027-8424

Publication Date

June 22, 2004

Volume

101

Issue

25

Start / End Page

9387 / 9392

Location

United States

Related Subject Headings

  • Transcription Factors
  • TRPC Cation Channels
  • Promoter Regions, Genetic
  • Phosphoproteins
  • Nuclear Proteins
  • Neuromuscular Junction
  • NFATC Transcription Factors
  • Muscle, Skeletal
  • Muscle Proteins
  • Muscle Contraction