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Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling.

Publication ,  Journal Article
Datto, M; Wang, X-F
Published in: Cell
April 8, 2005

Effects of the cytokine TGF-beta can be dampened by E3 ubiquitin ligases that target specific Smads, the TGF-beta signal transducers, for proteolytic destruction. Two papers in this issue of Cell highlight the importance of this mechanism in regulating the in vivo effects of TGF-beta. The first paper identifies and characterizes a novel Smad4 ubiquitin ligase, and the second paper redefines the role of a previously identified Smad1 ubiquitin ligase, Smurf-1 (Dupont et al., 2005; Yamashita et al., 2005).

Duke Scholars

Published In

Cell

DOI

ISSN

0092-8674

Publication Date

April 8, 2005

Volume

121

Issue

1

Start / End Page

2 / 4

Location

United States

Related Subject Headings

  • Xenopus
  • Ubiquitin-Protein Ligases
  • Transforming Growth Factor beta
  • Trans-Activators
  • Smad4 Protein
  • Signal Transduction
  • Receptors, Growth Factor
  • Protein Denaturation
  • Osteoblasts
  • Mice
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Datto, M., & Wang, X.-F. (2005). Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling. Cell, 121(1), 2–4. https://doi.org/10.1016/j.cell.2005.03.017
Datto, M., and X. -. F. Wang. “Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling.Cell 121, no. 1 (April 8, 2005): 2–4. https://doi.org/10.1016/j.cell.2005.03.017.
Datto, M., and X. .. F. Wang. “Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling.Cell, vol. 121, no. 1, Apr. 2005, pp. 2–4. Pubmed, doi:10.1016/j.cell.2005.03.017.
Journal cover image

Published In

Cell

DOI

ISSN

0092-8674

Publication Date

April 8, 2005

Volume

121

Issue

1

Start / End Page

2 / 4

Location

United States

Related Subject Headings

  • Xenopus
  • Ubiquitin-Protein Ligases
  • Transforming Growth Factor beta
  • Trans-Activators
  • Smad4 Protein
  • Signal Transduction
  • Receptors, Growth Factor
  • Protein Denaturation
  • Osteoblasts
  • Mice