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Fluorine-18 labeled chemotactic peptides: a potential approach for the PET imaging of bacterial infection.

Publication ,  Journal Article
Vaidyanathan, G; Zalutsky, MR
Published in: Nucl Med Biol
August 1995

A potent chemotactic peptide, formyl-norleucyl-leucyl-phenylalanyl-norleucyl-tyrosyl-lysine was derivatized by reaction with N-succinimidyl 4-fluorobenzoate. This derivatized peptide bound to human polymorphonuclear leukocytes in vitro and exhibited biological activity in a superoxide production assay. Peptide labeling using N-succinimidyl 4-[18F]fluorobenzoate was accomplished in reasonable yields with 10-15 mCi of labeled peptide available per 100 Ci of [18F]fluoride. With the exception of the gastrointestinal tract, clearance of activity from tissues following injection of this peptide in normal mice was rapid. Although preliminary in nature, these results suggest that 18F-labeled chemotactic peptides should be investigated as potential agents for positron emission tomographic imaging of bacterial infections.

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Published In

Nucl Med Biol

DOI

ISSN

0969-8051

Publication Date

August 1995

Volume

22

Issue

6

Start / End Page

759 / 764

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed
  • Tissue Distribution
  • Succinimides
  • Receptors, Peptide
  • Receptors, Immunologic
  • Receptors, Formyl Peptide
  • Oligopeptides
  • Nuclear Medicine & Medical Imaging
  • Neutrophils
  • N-Formylmethionine Leucyl-Phenylalanine
 

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Vaidyanathan, G., & Zalutsky, M. R. (1995). Fluorine-18 labeled chemotactic peptides: a potential approach for the PET imaging of bacterial infection. Nucl Med Biol, 22(6), 759–764. https://doi.org/10.1016/0969-8051(95)00028-v
Vaidyanathan, G., and M. R. Zalutsky. “Fluorine-18 labeled chemotactic peptides: a potential approach for the PET imaging of bacterial infection.Nucl Med Biol 22, no. 6 (August 1995): 759–64. https://doi.org/10.1016/0969-8051(95)00028-v.
Vaidyanathan, G., and M. R. Zalutsky. “Fluorine-18 labeled chemotactic peptides: a potential approach for the PET imaging of bacterial infection.Nucl Med Biol, vol. 22, no. 6, Aug. 1995, pp. 759–64. Pubmed, doi:10.1016/0969-8051(95)00028-v.
Journal cover image

Published In

Nucl Med Biol

DOI

ISSN

0969-8051

Publication Date

August 1995

Volume

22

Issue

6

Start / End Page

759 / 764

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed
  • Tissue Distribution
  • Succinimides
  • Receptors, Peptide
  • Receptors, Immunologic
  • Receptors, Formyl Peptide
  • Oligopeptides
  • Nuclear Medicine & Medical Imaging
  • Neutrophils
  • N-Formylmethionine Leucyl-Phenylalanine