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No-carrier-added meta-[123I]iodobenzylguanidine: synthesis and preliminary evaluation.

Publication ,  Journal Article
Vaidyanathan, G; Zalutsky, MR
Published in: Nucl Med Biol
January 1995

No-carrier-added [123I]MIBG was prepared from 3-(trimethylsilyl)benzylguanidine in 80-90% yield. Binding of this tracer to SK-N-SH human neuroblastoma cells maintained a constant level of > 50% over 2-3 log activity range. In comparison, the binding of [123I]MIBG prepared by isotopic exchange steadily decreased with dose. Biodistribution studies in normal mice demonstrated maximal concentrations in heart and adrenals for both preparations. In heart, significant 1.5-3.0 times higher levels (P < 0.05) were seen for the no-carrier-added preparation. Radiation dosimetry calculations suggest that the no-carrier-added preparation would increase the dose received by several tissues, most notably the heart where a 91% increase in dose is predicted.

Duke Scholars

Published In

Nucl Med Biol

DOI

ISSN

0969-8051

Publication Date

January 1995

Volume

22

Issue

1

Start / End Page

61 / 64

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Tissue Distribution
  • Radiation Dosage
  • Nuclear Medicine & Medical Imaging
  • Mice, Inbred BALB C
  • Mice
  • Iodobenzenes
  • Iodine Radioisotopes
  • Humans
  • Cell Line
 

Citation

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Vaidyanathan, G., & Zalutsky, M. R. (1995). No-carrier-added meta-[123I]iodobenzylguanidine: synthesis and preliminary evaluation. Nucl Med Biol, 22(1), 61–64. https://doi.org/10.1016/0969-8051(94)00078-x
Vaidyanathan, G., and M. R. Zalutsky. “No-carrier-added meta-[123I]iodobenzylguanidine: synthesis and preliminary evaluation.Nucl Med Biol 22, no. 1 (January 1995): 61–64. https://doi.org/10.1016/0969-8051(94)00078-x.
Vaidyanathan G, Zalutsky MR. No-carrier-added meta-[123I]iodobenzylguanidine: synthesis and preliminary evaluation. Nucl Med Biol. 1995 Jan;22(1):61–4.
Vaidyanathan, G., and M. R. Zalutsky. “No-carrier-added meta-[123I]iodobenzylguanidine: synthesis and preliminary evaluation.Nucl Med Biol, vol. 22, no. 1, Jan. 1995, pp. 61–64. Pubmed, doi:10.1016/0969-8051(94)00078-x.
Vaidyanathan G, Zalutsky MR. No-carrier-added meta-[123I]iodobenzylguanidine: synthesis and preliminary evaluation. Nucl Med Biol. 1995 Jan;22(1):61–64.
Journal cover image

Published In

Nucl Med Biol

DOI

ISSN

0969-8051

Publication Date

January 1995

Volume

22

Issue

1

Start / End Page

61 / 64

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Tissue Distribution
  • Radiation Dosage
  • Nuclear Medicine & Medical Imaging
  • Mice, Inbred BALB C
  • Mice
  • Iodobenzenes
  • Iodine Radioisotopes
  • Humans
  • Cell Line