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Mecamylamine moderates cue-induced emotional responses in smokers.

Publication ,  Journal Article
McClernon, FJ; Rose, JE
Published in: Addict Behav
May 2005

The nicotinic antagonist, mecamylamine, has been shown to reduce cue-elicited cocaine craving and to aid in smoking cessation. In a within-subjects design, 16 dependent smokers received mecamylamine (10 mg) or placebo capsules on two different days. Subjects imagined smoking urge and non-urge scenarios after smoking their usual brand vs. denicotinized cigarettes. Smoking usual-brand cigarettes produced greater positive effects and mecamylamine blocked heart rate (HR) boost and cigarette sensory impact. Mecamylamine also resulted in greater craving and less calmness, regardless of cigarette smoked. Urge script imagination in the mecamylamine+denicotinized condition resulted in calmness similar to usual-brand conditions and higher than the placebo+denicotinized condition. A similar trend was observed for negative affect. These results suggest that mecamylamine can moderate smoking cue-induced emotional responses in smokers.

Duke Scholars

Published In

Addict Behav

DOI

ISSN

0306-4603

Publication Date

May 2005

Volume

30

Issue

4

Start / End Page

741 / 753

Location

England

Related Subject Headings

  • Substance Abuse
  • Smoking Cessation
  • Smoking
  • Sensation
  • Nicotinic Antagonists
  • Middle Aged
  • Mecamylamine
  • Male
  • Humans
  • Heart Rate
 

Citation

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McClernon, F. J., & Rose, J. E. (2005). Mecamylamine moderates cue-induced emotional responses in smokers. Addict Behav, 30(4), 741–753. https://doi.org/10.1016/j.addbeh.2004.08.020
McClernon, F Joseph, and Jed E. Rose. “Mecamylamine moderates cue-induced emotional responses in smokers.Addict Behav 30, no. 4 (May 2005): 741–53. https://doi.org/10.1016/j.addbeh.2004.08.020.
McClernon FJ, Rose JE. Mecamylamine moderates cue-induced emotional responses in smokers. Addict Behav. 2005 May;30(4):741–53.
McClernon, F. Joseph, and Jed E. Rose. “Mecamylamine moderates cue-induced emotional responses in smokers.Addict Behav, vol. 30, no. 4, May 2005, pp. 741–53. Pubmed, doi:10.1016/j.addbeh.2004.08.020.
McClernon FJ, Rose JE. Mecamylamine moderates cue-induced emotional responses in smokers. Addict Behav. 2005 May;30(4):741–753.
Journal cover image

Published In

Addict Behav

DOI

ISSN

0306-4603

Publication Date

May 2005

Volume

30

Issue

4

Start / End Page

741 / 753

Location

England

Related Subject Headings

  • Substance Abuse
  • Smoking Cessation
  • Smoking
  • Sensation
  • Nicotinic Antagonists
  • Middle Aged
  • Mecamylamine
  • Male
  • Humans
  • Heart Rate