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Saliva nicotine as an index of plasma levels in nicotine skin patch users.

Publication ,  Journal Article
Rose, JE; Levin, ED; Benowitz, N
Published in: Ther Drug Monit
October 1993

This study examined whether salivary nicotine concentrations would provide a useful index of plasma concentrations in studies of the effects of transdermal nicotine administration. Twenty-four subject smokers abstained from smoking for 12 h prior to admission to a clinical research unit ward and for 36 h while remaining confined to the ward. Three doses of nicotine skin patches were applied to different groups of subjects, and blood and saliva samples were collected at several time points. Saliva flow was stimulated by three different methods: (a) sucking on a lemon candy, (b) dissolving a sugar cube in the mouth, and (c) chewing on parafilm. Nicotine and cotinine concentrations were measured in both saliva and blood using gas chromatography. There was a high correlation between blood and saliva values of nicotine (r = 0.82). Overall, saliva nicotine concentrations were approximately 8.1 times higher than those of plasma. Saliva and blood cotinine concentrations were also highly correlated (r = 0.94), replicating results of previous studies. Results suggest that saliva nicotine may be a useful marker of nicotine intake during nicotine skin patch treatment. Saliva collection may be advantageous under conditions in which blood collection is impractical and may provide greater sensitivity because of the high concentration of nicotine in saliva relative to that in blood.

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Published In

Ther Drug Monit

DOI

ISSN

0163-4356

Publication Date

October 1993

Volume

15

Issue

5

Start / End Page

431 / 435

Location

United States

Related Subject Headings

  • Saliva
  • Pharmacology & Pharmacy
  • Nicotine
  • Middle Aged
  • Male
  • Hydrogen-Ion Concentration
  • Humans
  • Female
  • Delayed-Action Preparations
  • Cotinine
 

Citation

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Rose, J. E., Levin, E. D., & Benowitz, N. (1993). Saliva nicotine as an index of plasma levels in nicotine skin patch users. Ther Drug Monit, 15(5), 431–435. https://doi.org/10.1097/00007691-199310000-00012
Rose, J. E., E. D. Levin, and N. Benowitz. “Saliva nicotine as an index of plasma levels in nicotine skin patch users.Ther Drug Monit 15, no. 5 (October 1993): 431–35. https://doi.org/10.1097/00007691-199310000-00012.
Rose JE, Levin ED, Benowitz N. Saliva nicotine as an index of plasma levels in nicotine skin patch users. Ther Drug Monit. 1993 Oct;15(5):431–5.
Rose, J. E., et al. “Saliva nicotine as an index of plasma levels in nicotine skin patch users.Ther Drug Monit, vol. 15, no. 5, Oct. 1993, pp. 431–35. Pubmed, doi:10.1097/00007691-199310000-00012.
Rose JE, Levin ED, Benowitz N. Saliva nicotine as an index of plasma levels in nicotine skin patch users. Ther Drug Monit. 1993 Oct;15(5):431–435.

Published In

Ther Drug Monit

DOI

ISSN

0163-4356

Publication Date

October 1993

Volume

15

Issue

5

Start / End Page

431 / 435

Location

United States

Related Subject Headings

  • Saliva
  • Pharmacology & Pharmacy
  • Nicotine
  • Middle Aged
  • Male
  • Hydrogen-Ion Concentration
  • Humans
  • Female
  • Delayed-Action Preparations
  • Cotinine