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Chronic nicotine reverses working memory deficits caused by lesions of the fimbria or medial basalocortical projection.

Publication ,  Journal Article
Levin, ED; Christopher, NC; Briggs, SJ; Rose, JE
Published in: Brain Res Cogn Brain Res
October 1993

Nicotine has been found in a variety of studies to improve performance in memory tasks. This study was conducted to determine if chronic nicotine administration is useful in counteracting the working memory deficits seen after lesions of the fimbria or the medial basalocortical projection. Rats were trained to asymptotic performance on a working memory version of the radial-arm maze. Then, they were given knife cut lesions of the fimbria or the medial basalocortical projection or underwent sham surgeries. At the time of surgery, rats in each treatment group were implanted with either nicotine-containing or placebo glass and Silastic pellets. Rats with fimbria or basalocortical lesions showed a significant decline in working memory performance. Chronic nicotine significantly improved choice accuracy in both lesioned and unlesioned rats. Nicotine treatment restored performance of the lesioned rats to control levels. These data show that in addition to improving memory performance in normal rats, nicotine can counteract lesion-induced memory impairments. Nicotine also may be useful for treatment of disease-related memory impairments such as seen in Alzheimer's disease.

Duke Scholars

Published In

Brain Res Cogn Brain Res

DOI

ISSN

0926-6410

Publication Date

October 1993

Volume

1

Issue

3

Start / End Page

137 / 143

Location

Netherlands

Related Subject Headings

  • Time Factors
  • Synaptic Transmission
  • Reaction Time
  • Rats, Sprague-Dawley
  • Rats
  • Nicotine
  • Motor Activity
  • Memory Disorders
  • Memory
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Levin, E. D., Christopher, N. C., Briggs, S. J., & Rose, J. E. (1993). Chronic nicotine reverses working memory deficits caused by lesions of the fimbria or medial basalocortical projection. Brain Res Cogn Brain Res, 1(3), 137–143. https://doi.org/10.1016/0926-6410(93)90021-v
Levin, E. D., N. C. Christopher, S. J. Briggs, and J. E. Rose. “Chronic nicotine reverses working memory deficits caused by lesions of the fimbria or medial basalocortical projection.Brain Res Cogn Brain Res 1, no. 3 (October 1993): 137–43. https://doi.org/10.1016/0926-6410(93)90021-v.
Levin ED, Christopher NC, Briggs SJ, Rose JE. Chronic nicotine reverses working memory deficits caused by lesions of the fimbria or medial basalocortical projection. Brain Res Cogn Brain Res. 1993 Oct;1(3):137–43.
Levin, E. D., et al. “Chronic nicotine reverses working memory deficits caused by lesions of the fimbria or medial basalocortical projection.Brain Res Cogn Brain Res, vol. 1, no. 3, Oct. 1993, pp. 137–43. Pubmed, doi:10.1016/0926-6410(93)90021-v.
Levin ED, Christopher NC, Briggs SJ, Rose JE. Chronic nicotine reverses working memory deficits caused by lesions of the fimbria or medial basalocortical projection. Brain Res Cogn Brain Res. 1993 Oct;1(3):137–143.
Journal cover image

Published In

Brain Res Cogn Brain Res

DOI

ISSN

0926-6410

Publication Date

October 1993

Volume

1

Issue

3

Start / End Page

137 / 143

Location

Netherlands

Related Subject Headings

  • Time Factors
  • Synaptic Transmission
  • Reaction Time
  • Rats, Sprague-Dawley
  • Rats
  • Nicotine
  • Motor Activity
  • Memory Disorders
  • Memory
  • Male