Chronic nicotine and withdrawal effects on radial-arm maze performance in rats.
Publication
, Journal Article
Levin, ED; Lee, C; Rose, JE; Reyes, A; Ellison, G; Jarvik, M; Gritz, E
Published in: Behav Neural Biol
March 1990
Rats were tested for choice accuracy in an eight-arm radial maze during and after chronic administration of nicotine via subcutaneously implanted glass and Silastic capsules. Nicotine administration significantly improved choice accuracy relative to controls. The effect gradually became apparent over the first 2 weeks of exposure and persisted through the third week. Surprisingly, the significant facilitation of the nicotine-treated rats relative to controls continued for 2 weeks after the end of nicotine administration. No effects of nicotine were seen on choice latency or the strategy to make adjacent arm entries.
Duke Scholars
Published In
Behav Neural Biol
DOI
ISSN
0163-1047
Publication Date
March 1990
Volume
53
Issue
2
Start / End Page
269 / 276
Location
United States
Related Subject Headings
- Substance Withdrawal Syndrome
- Rats, Inbred Strains
- Rats
- Orientation
- Nicotine
- Mental Recall
- Male
- Drug Implants
- Discrimination Learning
- Choice Behavior
Citation
APA
Chicago
ICMJE
MLA
NLM
Levin, E. D., Lee, C., Rose, J. E., Reyes, A., Ellison, G., Jarvik, M., & Gritz, E. (1990). Chronic nicotine and withdrawal effects on radial-arm maze performance in rats. Behav Neural Biol, 53(2), 269–276. https://doi.org/10.1016/0163-1047(90)90509-5
Levin, E. D., C. Lee, J. E. Rose, A. Reyes, G. Ellison, M. Jarvik, and E. Gritz. “Chronic nicotine and withdrawal effects on radial-arm maze performance in rats.” Behav Neural Biol 53, no. 2 (March 1990): 269–76. https://doi.org/10.1016/0163-1047(90)90509-5.
Levin ED, Lee C, Rose JE, Reyes A, Ellison G, Jarvik M, et al. Chronic nicotine and withdrawal effects on radial-arm maze performance in rats. Behav Neural Biol. 1990 Mar;53(2):269–76.
Levin, E. D., et al. “Chronic nicotine and withdrawal effects on radial-arm maze performance in rats.” Behav Neural Biol, vol. 53, no. 2, Mar. 1990, pp. 269–76. Pubmed, doi:10.1016/0163-1047(90)90509-5.
Levin ED, Lee C, Rose JE, Reyes A, Ellison G, Jarvik M, Gritz E. Chronic nicotine and withdrawal effects on radial-arm maze performance in rats. Behav Neural Biol. 1990 Mar;53(2):269–276.
Published In
Behav Neural Biol
DOI
ISSN
0163-1047
Publication Date
March 1990
Volume
53
Issue
2
Start / End Page
269 / 276
Location
United States
Related Subject Headings
- Substance Withdrawal Syndrome
- Rats, Inbred Strains
- Rats
- Orientation
- Nicotine
- Mental Recall
- Male
- Drug Implants
- Discrimination Learning
- Choice Behavior