Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Concurrent agonist-antagonist administration for the analysis and treatment of drug dependence.

Publication ,  Journal Article
Rose, JE; Levin, ED
Published in: Pharmacol Biochem Behav
January 1992

Two key strategies for the treatment of drug dependence involve the use of agonists to substitute for the abused drug and the use of antagonists to block the reinforcing actions maintaining drug self-administration. A different strategy for the treatment of drug dependence is outlined, comprising the concurrent administration of an agonist and an antagonist. Concurrent administration of an agonist with an antagonist, in the proper ratio, should produce maximal occupancy of receptors and attenuation of the reinforcing actions of the abused drug. The addict would be relatively "insulated" from the reinforcing effects of the abused drug; at the same time the balance of agonist and antagonist effects is predicted to prevent withdrawal symptoms or intoxication resulting from an under- or over-stimulation of drug receptors. Advantages over the use of agonists alone and antagonists alone, and over mixed agonist-antagonist molecules, are discussed. Application of concurrent agonist-antagonist administration to the analysis of mechanisms underlying nondrug reinforcement and to the treatment of disorders involving receptor disregulation is also described.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Pharmacol Biochem Behav

DOI

ISSN

0091-3057

Publication Date

January 1992

Volume

41

Issue

1

Start / End Page

219 / 226

Location

United States

Related Subject Headings

  • Substance-Related Disorders
  • Neurology & Neurosurgery
  • Humans
  • Drug Antagonism
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences
  • 3209 Neurosciences
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rose, J. E., & Levin, E. D. (1992). Concurrent agonist-antagonist administration for the analysis and treatment of drug dependence. Pharmacol Biochem Behav, 41(1), 219–226. https://doi.org/10.1016/0091-3057(92)90086-u
Rose, J. E., and E. D. Levin. “Concurrent agonist-antagonist administration for the analysis and treatment of drug dependence.Pharmacol Biochem Behav 41, no. 1 (January 1992): 219–26. https://doi.org/10.1016/0091-3057(92)90086-u.
Rose JE, Levin ED. Concurrent agonist-antagonist administration for the analysis and treatment of drug dependence. Pharmacol Biochem Behav. 1992 Jan;41(1):219–26.
Rose, J. E., and E. D. Levin. “Concurrent agonist-antagonist administration for the analysis and treatment of drug dependence.Pharmacol Biochem Behav, vol. 41, no. 1, Jan. 1992, pp. 219–26. Pubmed, doi:10.1016/0091-3057(92)90086-u.
Rose JE, Levin ED. Concurrent agonist-antagonist administration for the analysis and treatment of drug dependence. Pharmacol Biochem Behav. 1992 Jan;41(1):219–226.
Journal cover image

Published In

Pharmacol Biochem Behav

DOI

ISSN

0091-3057

Publication Date

January 1992

Volume

41

Issue

1

Start / End Page

219 / 226

Location

United States

Related Subject Headings

  • Substance-Related Disorders
  • Neurology & Neurosurgery
  • Humans
  • Drug Antagonism
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences
  • 3209 Neurosciences
  • 1115 Pharmacology and Pharmaceutical Sciences