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Significant prolongation of hamster liver transplant survival in Lewis rats by total-lymphoid irradiation, cyclosporine, and splenectomy.

Publication ,  Journal Article
Yamaguchi, Y; Halperin, EC; Harland, RC; Wyble, C; Bollinger, RR
Published in: Transplantation
January 1990

The effects of total lymphoid irradiation, cyclosporine and splenectomy alone and in combination have been studied in liver transplants from the LVG hamster to the LEW rat. Neither CsA alone, splenectomy alone, nor TLI alone prolonged graft survival. CsA/splenectomy and TLI/CsA produced significant prolongation of graft survival. TLI/CsA/splenectomy prolonged graft survival by over sixfold compared with controls. While CsA alone was ineffective in reducing lymphocytotoxic antidonor antibody, splenectomy alone or CsA/splenectomy did significantly suppress production of antibody. Only very low levels of antibody could be detected in animals treated with TLI/CsA/splenectomy. TLI/CsA/splenectomy has an immunosuppressive effect sufficient to significantly prolong liver graft survival in the LVG hamster to LEW rat combination and may represent a promising treatment protocol in experimental cross-species transplantation.

Duke Scholars

Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

January 1990

Volume

49

Issue

1

Start / End Page

13 / 17

Location

United States

Related Subject Headings

  • Transplantation, Heterologous
  • Surgery
  • Splenectomy
  • Rats, Inbred Lew
  • Rats
  • Male
  • Lymphoid Tissue
  • Liver Transplantation
  • Immunosuppression Therapy
  • Graft Survival
 

Citation

APA
Chicago
ICMJE
MLA
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Yamaguchi, Y., Halperin, E. C., Harland, R. C., Wyble, C., & Bollinger, R. R. (1990). Significant prolongation of hamster liver transplant survival in Lewis rats by total-lymphoid irradiation, cyclosporine, and splenectomy. Transplantation, 49(1), 13–17. https://doi.org/10.1097/00007890-199001000-00003
Yamaguchi, Y., E. C. Halperin, R. C. Harland, C. Wyble, and R. R. Bollinger. “Significant prolongation of hamster liver transplant survival in Lewis rats by total-lymphoid irradiation, cyclosporine, and splenectomy.Transplantation 49, no. 1 (January 1990): 13–17. https://doi.org/10.1097/00007890-199001000-00003.
Yamaguchi Y, Halperin EC, Harland RC, Wyble C, Bollinger RR. Significant prolongation of hamster liver transplant survival in Lewis rats by total-lymphoid irradiation, cyclosporine, and splenectomy. Transplantation. 1990 Jan;49(1):13–7.
Yamaguchi, Y., et al. “Significant prolongation of hamster liver transplant survival in Lewis rats by total-lymphoid irradiation, cyclosporine, and splenectomy.Transplantation, vol. 49, no. 1, Jan. 1990, pp. 13–17. Pubmed, doi:10.1097/00007890-199001000-00003.
Yamaguchi Y, Halperin EC, Harland RC, Wyble C, Bollinger RR. Significant prolongation of hamster liver transplant survival in Lewis rats by total-lymphoid irradiation, cyclosporine, and splenectomy. Transplantation. 1990 Jan;49(1):13–17.

Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

January 1990

Volume

49

Issue

1

Start / End Page

13 / 17

Location

United States

Related Subject Headings

  • Transplantation, Heterologous
  • Surgery
  • Splenectomy
  • Rats, Inbred Lew
  • Rats
  • Male
  • Lymphoid Tissue
  • Liver Transplantation
  • Immunosuppression Therapy
  • Graft Survival