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Effect of continuous complement inhibition using soluble complement receptor type 1 on survival of pig-to-primate cardiac xenografts.

Publication ,  Journal Article
Pruitt, SK; Bollinger, RR; Collins, BH; Marsh, HC; Levin, JL; Rudolph, AR; Baldwin, WM; Sanfilippo, F
Published in: Transplantation
March 27, 1997

A single bolus of soluble complement (C) receptor type 1 (sCR1, TP-10) has been shown to delay hyperacute rejection (HAR) of porcine cardiac xenografts (Xgs) by primate recipients. In these recipients, C activity slowly returned and C deposition was noted in the Xgs at rejection. To evaluate the effect of sustained C inhibition using sCR1 on HAR, two additional cynomolgus monkeys received porcine cardiac Xgs and a continuous infusion of sCR1. In the first recipient, Xgs survival was 5 days (120+ hr), whereas in the second, Xg survival was 7 days (168+ hr). Serial biopsies of the Xgs were remarkable for an increasing cellular infiltrate composed predominantly of neutrophils and macrophages, and the development of edema, hemorrhage, and myocyte necrosis. These findings suggest that once C-mediated HAR has been inhibited, infiltration of the Xg by these cells may lead to accelerated acute rejection, which is an additional barrier to successful longer term Xg survival.

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Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

March 27, 1997

Volume

63

Issue

6

Start / End Page

900 / 902

Location

United States

Related Subject Headings

  • Transplantation, Heterologous
  • Time Factors
  • Swine
  • Surgery
  • Receptors, Complement
  • Myocardial Reperfusion
  • Macaca fascicularis
  • Infusions, Intravenous
  • Immunosuppression Therapy
  • Heart Transplantation
 

Citation

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Pruitt, S. K., Bollinger, R. R., Collins, B. H., Marsh, H. C., Levin, J. L., Rudolph, A. R., … Sanfilippo, F. (1997). Effect of continuous complement inhibition using soluble complement receptor type 1 on survival of pig-to-primate cardiac xenografts. Transplantation, 63(6), 900–902. https://doi.org/10.1097/00007890-199703270-00017
Pruitt, S. K., R. R. Bollinger, B. H. Collins, H. C. Marsh, J. L. Levin, A. R. Rudolph, W. M. Baldwin, and F. Sanfilippo. “Effect of continuous complement inhibition using soluble complement receptor type 1 on survival of pig-to-primate cardiac xenografts.Transplantation 63, no. 6 (March 27, 1997): 900–902. https://doi.org/10.1097/00007890-199703270-00017.
Pruitt SK, Bollinger RR, Collins BH, Marsh HC, Levin JL, Rudolph AR, et al. Effect of continuous complement inhibition using soluble complement receptor type 1 on survival of pig-to-primate cardiac xenografts. Transplantation. 1997 Mar 27;63(6):900–2.
Pruitt, S. K., et al. “Effect of continuous complement inhibition using soluble complement receptor type 1 on survival of pig-to-primate cardiac xenografts.Transplantation, vol. 63, no. 6, Mar. 1997, pp. 900–02. Pubmed, doi:10.1097/00007890-199703270-00017.
Pruitt SK, Bollinger RR, Collins BH, Marsh HC, Levin JL, Rudolph AR, Baldwin WM, Sanfilippo F. Effect of continuous complement inhibition using soluble complement receptor type 1 on survival of pig-to-primate cardiac xenografts. Transplantation. 1997 Mar 27;63(6):900–902.

Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

March 27, 1997

Volume

63

Issue

6

Start / End Page

900 / 902

Location

United States

Related Subject Headings

  • Transplantation, Heterologous
  • Time Factors
  • Swine
  • Surgery
  • Receptors, Complement
  • Myocardial Reperfusion
  • Macaca fascicularis
  • Infusions, Intravenous
  • Immunosuppression Therapy
  • Heart Transplantation