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Neuropeptide Y functions as a physiologic regulator of cephalic phase acid secretion.

Publication ,  Journal Article
Lee, MC; Lawson, DC; Pappas, TN
Published in: Regul Pept
August 4, 1994

Neuropeptide Y (NPY) has been established as a potent orexigenic peptide, and recent studies suggest that NPY stimulates cephalic phase secretion as well. However, it is not known whether NPY's effects are pharmacologic or physiologic. In order to determine the physiologic significance of NPY, we examined the effects of two putative NPY receptor antagonists, PYX-1 and PYX-2, on sham feeding and gastric acid secretion in dogs. Our results demonstrate that intracerebroventricular (i.c.v.) injection of PYX-1 and PYX-2 at 1000 pmol/kg doses significantly suppresses the gastric acid response to sham feeding in dogs. The volumes sham fed were not significantly altered with i.c.v. administration of the antagonists. Peripheral administration did not affect acid secretion nor sham feeding volumes. Our data suggest that central administration of the novel NPY antagonists, PYX-1 and PYX-2, results in significant suppression of acid secretion in dogs. This supports our hypothesis that NPY functions as a physiologic modulator of cephalic phase acid secretion.

Duke Scholars

Published In

Regul Pept

DOI

ISSN

0167-0115

Publication Date

August 4, 1994

Volume

52

Issue

3

Start / End Page

227 / 234

Location

Netherlands

Related Subject Headings

  • Receptors, Neuropeptide Y
  • Peptide Fragments
  • Neuropeptide Y
  • Gastric Acid
  • Endocrinology & Metabolism
  • Eating
  • Dogs
  • Animals
  • 3404 Medicinal and biomolecular chemistry
  • 3205 Medical biochemistry and metabolomics
 

Citation

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Lee, M. C., Lawson, D. C., & Pappas, T. N. (1994). Neuropeptide Y functions as a physiologic regulator of cephalic phase acid secretion. Regul Pept, 52(3), 227–234. https://doi.org/10.1016/0167-0115(94)90057-4
Lee, M. C., D. C. Lawson, and T. N. Pappas. “Neuropeptide Y functions as a physiologic regulator of cephalic phase acid secretion.Regul Pept 52, no. 3 (August 4, 1994): 227–34. https://doi.org/10.1016/0167-0115(94)90057-4.
Lee MC, Lawson DC, Pappas TN. Neuropeptide Y functions as a physiologic regulator of cephalic phase acid secretion. Regul Pept. 1994 Aug 4;52(3):227–34.
Lee, M. C., et al. “Neuropeptide Y functions as a physiologic regulator of cephalic phase acid secretion.Regul Pept, vol. 52, no. 3, Aug. 1994, pp. 227–34. Pubmed, doi:10.1016/0167-0115(94)90057-4.
Lee MC, Lawson DC, Pappas TN. Neuropeptide Y functions as a physiologic regulator of cephalic phase acid secretion. Regul Pept. 1994 Aug 4;52(3):227–234.
Journal cover image

Published In

Regul Pept

DOI

ISSN

0167-0115

Publication Date

August 4, 1994

Volume

52

Issue

3

Start / End Page

227 / 234

Location

Netherlands

Related Subject Headings

  • Receptors, Neuropeptide Y
  • Peptide Fragments
  • Neuropeptide Y
  • Gastric Acid
  • Endocrinology & Metabolism
  • Eating
  • Dogs
  • Animals
  • 3404 Medicinal and biomolecular chemistry
  • 3205 Medical biochemistry and metabolomics