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Gastrointestinal hemorrhage due to complicated gastroduodenal ulcer disease in liver transplant patients taking sirolimus.

Publication ,  Journal Article
Smith, AD; Bai, D; Marroquin, CE; Tuttle-Newhall, JE; Desai, DM; Collins, BH; Muir, A; Kuo, PC; McHutchison, J; Rockey, DC
Published in: Clin Transplant
April 2005

Sirolimus is emerging as a popular immunosuppressive agent for patients undergoing solid organ and pancreatic cell transplantation. Here, we report the clinical courses of three patients receiving sirolimus who developed aggressive gastroduodenal ulcer disease. One patient died from massive gastrointestinal bleeding, and ulcers in the other two patients healed only after discontinuation of sirolimus. We propose that the mechanism underlying this severe ulcer diathesis, and poor ulcer healing, was linked to the well-known inhibitory effects of sirolimus on wound healing. We propose that sirolimus should be used carefully (or even withheld) in patients with known or previous ulcer disease, and further that it should be used prudently and/or in conjunction with aggressive prophylaxis therapy in those at risk for ulcer disease.

Duke Scholars

Published In

Clin Transplant

DOI

ISSN

0902-0063

Publication Date

April 2005

Volume

19

Issue

2

Start / End Page

250 / 254

Location

Denmark

Related Subject Headings

  • Wound Healing
  • Surgery
  • Stomach Ulcer
  • Sirolimus
  • Peptic Ulcer Hemorrhage
  • Middle Aged
  • Melena
  • Male
  • Liver Transplantation
  • Immunosuppressive Agents
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Smith, A. D., Bai, D., Marroquin, C. E., Tuttle-Newhall, J. E., Desai, D. M., Collins, B. H., … Rockey, D. C. (2005). Gastrointestinal hemorrhage due to complicated gastroduodenal ulcer disease in liver transplant patients taking sirolimus. Clin Transplant, 19(2), 250–254. https://doi.org/10.1111/j.1399-0012.2005.00332.x
Smith, Alastair D., Diane Bai, Carlos E. Marroquin, Janet E. Tuttle-Newhall, Dev M. Desai, Bradley H. Collins, Andrew Muir, Paul C. Kuo, John McHutchison, and Don C. Rockey. “Gastrointestinal hemorrhage due to complicated gastroduodenal ulcer disease in liver transplant patients taking sirolimus.Clin Transplant 19, no. 2 (April 2005): 250–54. https://doi.org/10.1111/j.1399-0012.2005.00332.x.
Smith AD, Bai D, Marroquin CE, Tuttle-Newhall JE, Desai DM, Collins BH, et al. Gastrointestinal hemorrhage due to complicated gastroduodenal ulcer disease in liver transplant patients taking sirolimus. Clin Transplant. 2005 Apr;19(2):250–4.
Smith, Alastair D., et al. “Gastrointestinal hemorrhage due to complicated gastroduodenal ulcer disease in liver transplant patients taking sirolimus.Clin Transplant, vol. 19, no. 2, Apr. 2005, pp. 250–54. Pubmed, doi:10.1111/j.1399-0012.2005.00332.x.
Smith AD, Bai D, Marroquin CE, Tuttle-Newhall JE, Desai DM, Collins BH, Muir A, Kuo PC, McHutchison J, Rockey DC. Gastrointestinal hemorrhage due to complicated gastroduodenal ulcer disease in liver transplant patients taking sirolimus. Clin Transplant. 2005 Apr;19(2):250–254.
Journal cover image

Published In

Clin Transplant

DOI

ISSN

0902-0063

Publication Date

April 2005

Volume

19

Issue

2

Start / End Page

250 / 254

Location

Denmark

Related Subject Headings

  • Wound Healing
  • Surgery
  • Stomach Ulcer
  • Sirolimus
  • Peptic Ulcer Hemorrhage
  • Middle Aged
  • Melena
  • Male
  • Liver Transplantation
  • Immunosuppressive Agents