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Successful therapy for trilateral retinoblastoma.

Publication ,  Journal Article
Nelson, SC; Friedman, HS; Oakes, WJ; Halperin, EC; Tien, R; Fuller, GN; Hockenberger, B; Scroggs, MW; Moncino, M; Kurtzberg, J
Published in: Am J Ophthalmol
July 15, 1992

Trilateral retinoblastoma, the intracranial malignancy associated with bilateral retinoblastoma, is an uncommon and clinically aggressive malignancy with a uniformly fatal outcome. Three children with newly diagnosed trilateral retinoblastoma were treated with systemic (cyclophosphamide and vincristine) and intrathecal (methotrexate, hydrocortisone, and cytarabine) chemotherapy, as well as craniospinal irradiation (one patient) in addition to therapy of the eye lesions. All three patients have had partial or complete response of the pineal tumors to chemotherapy, with no active disease eight or more years, 33 or more months, and 12 or more months, respectively, after diagnosis of the lesions.

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Published In

Am J Ophthalmol

DOI

ISSN

0002-9394

Publication Date

July 15, 1992

Volume

114

Issue

1

Start / End Page

23 / 29

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Retinoblastoma
  • Pineal Gland
  • Pentetic Acid
  • Organometallic Compounds
  • Ophthalmology & Optometry
  • Male
  • Magnetic Resonance Imaging
  • Infant, Newborn
  • Infant
 

Citation

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Nelson, S. C., Friedman, H. S., Oakes, W. J., Halperin, E. C., Tien, R., Fuller, G. N., … Kurtzberg, J. (1992). Successful therapy for trilateral retinoblastoma. Am J Ophthalmol, 114(1), 23–29. https://doi.org/10.1016/s0002-9394(14)77408-2
Nelson, S. C., H. S. Friedman, W. J. Oakes, E. C. Halperin, R. Tien, G. N. Fuller, B. Hockenberger, M. W. Scroggs, M. Moncino, and J. Kurtzberg. “Successful therapy for trilateral retinoblastoma.Am J Ophthalmol 114, no. 1 (July 15, 1992): 23–29. https://doi.org/10.1016/s0002-9394(14)77408-2.
Nelson SC, Friedman HS, Oakes WJ, Halperin EC, Tien R, Fuller GN, et al. Successful therapy for trilateral retinoblastoma. Am J Ophthalmol. 1992 Jul 15;114(1):23–9.
Nelson, S. C., et al. “Successful therapy for trilateral retinoblastoma.Am J Ophthalmol, vol. 114, no. 1, July 1992, pp. 23–29. Pubmed, doi:10.1016/s0002-9394(14)77408-2.
Nelson SC, Friedman HS, Oakes WJ, Halperin EC, Tien R, Fuller GN, Hockenberger B, Scroggs MW, Moncino M, Kurtzberg J. Successful therapy for trilateral retinoblastoma. Am J Ophthalmol. 1992 Jul 15;114(1):23–29.
Journal cover image

Published In

Am J Ophthalmol

DOI

ISSN

0002-9394

Publication Date

July 15, 1992

Volume

114

Issue

1

Start / End Page

23 / 29

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Retinoblastoma
  • Pineal Gland
  • Pentetic Acid
  • Organometallic Compounds
  • Ophthalmology & Optometry
  • Male
  • Magnetic Resonance Imaging
  • Infant, Newborn
  • Infant