Recombinant activated factor VII and the anaesthetist.
Recombinant activated factor VII is a safe and effective for the treatment and prevention of haemorrhage in haemophiliacs with circulating inhibitors to replacement factors, and patients with Glanzmann's thrombasthenia refractory to platelet transfusion. By restoring thrombin generation on the surface of tissue factor bearing cells, such as activated platelets and monocytes, recombinant activated factor VII has the potential to effect haemostasis in the setting of many coagulopathic states encountered by the anaesthetist in the operating theatre or the intensive care unit. Case reports of successful rescue therapy make up the majority of the literature covering other, numerous, off-label uses of recombinant activated factor VII, although some randomised, controlled studies, mostly underpowered to address safety concerns, have been performed. However, off-label use is becoming increasingly popular judging by the number of published case reports. Additional randomised, controlled trials to determine the safe and appropriate use of this potentially valuable therapy in broader patient groups are eagerly awaited.
Duke Scholars
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Related Subject Headings
- Wounds and Injuries
- Recombinant Proteins
- Humans
- Hemostatics
- Hemostasis, Surgical
- Factor VIIa
- Factor VII
- Drug Administration Schedule
- Cardiac Surgical Procedures
- Blood Loss, Surgical
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Wounds and Injuries
- Recombinant Proteins
- Humans
- Hemostatics
- Hemostasis, Surgical
- Factor VIIa
- Factor VII
- Drug Administration Schedule
- Cardiac Surgical Procedures
- Blood Loss, Surgical