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In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus.

Publication ,  Journal Article
Steinbach, WJ; Schell, WA; Blankenship, JR; Onyewu, C; Heitman, J; Perfect, JR
Published in: Antimicrob Agents Chemother
May 2004

The optimal treatment for invasive aspergillosis remains elusive, despite the increased efficacy of newer agents. The immunosuppressants cyclosporine (CY), tacrolimus (FK506), and sirolimus (formerly called rapamycin) exhibit in vitro and in vivo activity against Candida albicans, Cryptococcus neoformans, and Saccharomyces cerevisiae, including fungicidal synergy with azole antifungals. We report here that both FK506 and CY exhibit a clear in vitro positive interaction with caspofungin against Aspergillus fumigatus by disk diffusion, microdilution checkerboard, and gross and microscopic morphological analyses. Microscopic morphological analyses indicate that the calcineurin inhibitors delay filamentation, and in combination with caspofungin there is a positive interaction. Our findings suggest a potential role for combination therapy with calcineurin pathway inhibitors and existing antifungal agents to augment activity against A. fumigatus.

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Published In

Antimicrob Agents Chemother

DOI

ISSN

0066-4804

Publication Date

May 2004

Volume

48

Issue

5

Start / End Page

1664 / 1669

Location

United States

Related Subject Headings

  • Voriconazole
  • Triazoles
  • Tacrolimus
  • Pyrimidines
  • Peptides, Cyclic
  • Peptides
  • Microbiology
  • Microbial Sensitivity Tests
  • Lipopeptides
  • Echinocandins
 

Citation

APA
Chicago
ICMJE
MLA
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Steinbach, W. J., Schell, W. A., Blankenship, J. R., Onyewu, C., Heitman, J., & Perfect, J. R. (2004). In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus. Antimicrob Agents Chemother, 48(5), 1664–1669. https://doi.org/10.1128/AAC.48.5.1664-1669.2004
Steinbach, William J., Wiley A. Schell, Jill R. Blankenship, Chiatogu Onyewu, Joseph Heitman, and John R. Perfect. “In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus.Antimicrob Agents Chemother 48, no. 5 (May 2004): 1664–69. https://doi.org/10.1128/AAC.48.5.1664-1669.2004.
Steinbach WJ, Schell WA, Blankenship JR, Onyewu C, Heitman J, Perfect JR. In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus. Antimicrob Agents Chemother. 2004 May;48(5):1664–9.
Steinbach, William J., et al. “In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus.Antimicrob Agents Chemother, vol. 48, no. 5, May 2004, pp. 1664–69. Pubmed, doi:10.1128/AAC.48.5.1664-1669.2004.
Steinbach WJ, Schell WA, Blankenship JR, Onyewu C, Heitman J, Perfect JR. In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus. Antimicrob Agents Chemother. 2004 May;48(5):1664–1669.

Published In

Antimicrob Agents Chemother

DOI

ISSN

0066-4804

Publication Date

May 2004

Volume

48

Issue

5

Start / End Page

1664 / 1669

Location

United States

Related Subject Headings

  • Voriconazole
  • Triazoles
  • Tacrolimus
  • Pyrimidines
  • Peptides, Cyclic
  • Peptides
  • Microbiology
  • Microbial Sensitivity Tests
  • Lipopeptides
  • Echinocandins