Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Clinical and electroencephalographic correlates in Rasmussen's encephalitis.

Publication ,  Journal Article
Andrews, PI; McNamara, JO; Lewis, DV
Published in: Epilepsia
February 1997

PURPOSE: Rasmussen's encephalitis (RE) is a progressive childhood disease characterized by unilateral brain dysfunction, seizures, and inflammatory histopathology. Converging lines of evidence suggest that an autoimmune process is important in the pathogenesis of RE. METHODS: Two patients with pathologically confirmed RE and increased levels of circulating glutamate receptor subunit (GluR3) antibodies were studied prospectively before, during, and after trials of plasmapheresis (PEX) and other immunomodulation. Frequency, duration, and intensity of clinical seizures were directly correlated with the abundance of interictal epileptiform activity on serial EEGs. RESULTS: Serial EEGs in these patients suggest that early in the course of RE interictal epileptiform activity is localized to the affected hemisphere and that disease progression is associated with increasingly frequent bilaterally synchronous and contralateral epileptiform activity. CONCLUSIONS: The clinical and EEG parameters of epileptogenesis were transiently diminished by PEX, which suggests that circulating factors induce dose-dependent, reversible epileptogenic effects in some patients with RE.

Duke Scholars

Published In

Epilepsia

DOI

ISSN

0013-9580

Publication Date

February 1997

Volume

38

Issue

2

Start / End Page

189 / 194

Location

United States

Related Subject Headings

  • Receptors, Glutamate
  • Plasmapheresis
  • Neurology & Neurosurgery
  • Humans
  • Functional Laterality
  • Female
  • Epilepsies, Partial
  • Encephalitis
  • Electroencephalography
  • Disease Progression
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Andrews, P. I., McNamara, J. O., & Lewis, D. V. (1997). Clinical and electroencephalographic correlates in Rasmussen's encephalitis. Epilepsia, 38(2), 189–194. https://doi.org/10.1111/j.1528-1157.1997.tb01096.x
Andrews, P. I., J. O. McNamara, and D. V. Lewis. “Clinical and electroencephalographic correlates in Rasmussen's encephalitis.Epilepsia 38, no. 2 (February 1997): 189–94. https://doi.org/10.1111/j.1528-1157.1997.tb01096.x.
Andrews PI, McNamara JO, Lewis DV. Clinical and electroencephalographic correlates in Rasmussen's encephalitis. Epilepsia. 1997 Feb;38(2):189–94.
Andrews, P. I., et al. “Clinical and electroencephalographic correlates in Rasmussen's encephalitis.Epilepsia, vol. 38, no. 2, Feb. 1997, pp. 189–94. Pubmed, doi:10.1111/j.1528-1157.1997.tb01096.x.
Andrews PI, McNamara JO, Lewis DV. Clinical and electroencephalographic correlates in Rasmussen's encephalitis. Epilepsia. 1997 Feb;38(2):189–194.
Journal cover image

Published In

Epilepsia

DOI

ISSN

0013-9580

Publication Date

February 1997

Volume

38

Issue

2

Start / End Page

189 / 194

Location

United States

Related Subject Headings

  • Receptors, Glutamate
  • Plasmapheresis
  • Neurology & Neurosurgery
  • Humans
  • Functional Laterality
  • Female
  • Epilepsies, Partial
  • Encephalitis
  • Electroencephalography
  • Disease Progression