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Limiting impairment of muscle function following ischemia and reperfusion in rabbits.

Publication ,  Journal Article
Zavitsanos, G; Huang, L; Panza, W; Serafin, D; Klitzman, B
Published in: J Reconstr Microsurg
April 1996

Reperfusion injury is a phenomenon complicating microvascular reconstruction. Extensive investigations of free-radical scavengers exist in the literature. The potential beneficial effects of verapamil, deferoxamine, and dimethylsulfoxide were studied in the rabbit forelimb subjected to 3 hr of tourniquet ischemia, followed by a period of reperfusion. Five minutes prior to tourniquet release, rabbits were given single intravenous infusions of normal saline, verapamil (0.2 mg/kg), deferoxamine (50 mg/kg), or dimethylsulfoxide (100 mg/kg). Following reperfusion, neither light microscopy nor laser Doppler flowmetry revealed significant differences between the sham and treated limbs. Muscle function was evaluated by measuring maximal twitch tensions in the flexor digitorum superficialis. Deterioration of muscle contractile function at 0.5, 3, and 24 hr after reperfusion was significantly improved by treatment with verapamil or deferoxamine. Conversely, dimethylsulfoxide worsened muscle function post ischemia. Dimethylsulfoxide does not appear to be beneficial, while verapamil and deferoxamine may be of benefit in mitigating reperfusion injury in microvascular transplantation.

Duke Scholars

Published In

J Reconstr Microsurg

DOI

ISSN

0743-684X

Publication Date

April 1996

Volume

12

Issue

3

Start / End Page

183 / 187

Location

United States

Related Subject Headings

  • Verapamil
  • Time Factors
  • Surgery
  • Reperfusion Injury
  • Rabbits
  • Muscle, Skeletal
  • Muscle Contraction
  • Male
  • Free Radical Scavengers
  • Forelimb
 

Citation

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Zavitsanos, G., Huang, L., Panza, W., Serafin, D., & Klitzman, B. (1996). Limiting impairment of muscle function following ischemia and reperfusion in rabbits. J Reconstr Microsurg, 12(3), 183–187. https://doi.org/10.1055/s-2007-1006474
Zavitsanos, G., L. Huang, W. Panza, D. Serafin, and B. Klitzman. “Limiting impairment of muscle function following ischemia and reperfusion in rabbits.J Reconstr Microsurg 12, no. 3 (April 1996): 183–87. https://doi.org/10.1055/s-2007-1006474.
Zavitsanos G, Huang L, Panza W, Serafin D, Klitzman B. Limiting impairment of muscle function following ischemia and reperfusion in rabbits. J Reconstr Microsurg. 1996 Apr;12(3):183–7.
Zavitsanos, G., et al. “Limiting impairment of muscle function following ischemia and reperfusion in rabbits.J Reconstr Microsurg, vol. 12, no. 3, Apr. 1996, pp. 183–87. Pubmed, doi:10.1055/s-2007-1006474.
Zavitsanos G, Huang L, Panza W, Serafin D, Klitzman B. Limiting impairment of muscle function following ischemia and reperfusion in rabbits. J Reconstr Microsurg. 1996 Apr;12(3):183–187.
Journal cover image

Published In

J Reconstr Microsurg

DOI

ISSN

0743-684X

Publication Date

April 1996

Volume

12

Issue

3

Start / End Page

183 / 187

Location

United States

Related Subject Headings

  • Verapamil
  • Time Factors
  • Surgery
  • Reperfusion Injury
  • Rabbits
  • Muscle, Skeletal
  • Muscle Contraction
  • Male
  • Free Radical Scavengers
  • Forelimb