Scholars@Duke publication: Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.

Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.

Publication , Journal Article

Caspi, A; Sugden, K; Moffitt, TE; Taylor, A; Craig, IW; Harrington, H; McClay, J; Mill, J; Martin, J; Braithwaite, A; Poulton, R

Published in: Science (New York, N.Y.)

July 2003

Published version (DOI)

In a prospective-longitudinal study of a representative birth cohort, we tested why stressful experiences lead to depression in some people but not in others. A functional polymorphism in the promoter region of the serotonin transporter (5-HT T) gene was found to moderate the influence of stressful life events on depression. Individuals with one or two copies of the short allele of the 5-HT T promoter polymorphism exhibited more depressive symptoms, diagnosable depression, and suicidality in relation to stressful life events than individuals homozygous for the long allele. This epidemiological study thus provides evidence of a gene-by-environment interaction, in which an individual's response to environmental insults is moderated by his or her genetic makeup.

Duke Scholars

Author Avshalom Caspi Psychology & Neuroscience

Author Karen Sugden

Author Terrie E. Moffitt Psychology & Neuroscience

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Published In

Science (New York, N.Y.)

DOI

10.1126/science.1083968

EISSN

1095-9203

ISSN

0036-8075

Publication Date

July 2003

Volume

301

Issue

5631

Start / End Page

386 / 389

Related Subject Headings

Suicide, Attempted
Stress, Psychological
Serotonin Plasma Membrane Transport Proteins
Promoter Regions, Genetic
Probability
Polymorphism, Genetic
Nerve Tissue Proteins
Monoamine Oxidase
Membrane Transport Proteins
Membrane Glycoproteins

Citation

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NLM

Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., … Poulton, R. (2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science (New York, N.Y.), 301(5631), 386–389. https://doi.org/10.1126/science.1083968

Caspi, Avshalom, Karen Sugden, Terrie E. Moffitt, Alan Taylor, Ian W. Craig, HonaLee Harrington, Joseph McClay, et al. “Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.” Science (New York, N.Y.) 301, no. 5631 (July 2003): 386–89. https://doi.org/10.1126/science.1083968.

Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science (New York, NY). 2003 Jul;301(5631):386–9.

Caspi, Avshalom, et al. “Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.” Science (New York, N.Y.), vol. 301, no. 5631, July 2003, pp. 386–89. Epmc, doi:10.1126/science.1083968.

Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, Poulton R. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science (New York, NY). 2003 Jul;301(5631):386–389.

Published In

Science (New York, N.Y.)

DOI

10.1126/science.1083968

EISSN

1095-9203

ISSN

0036-8075

Publication Date

July 2003

Volume

301

Issue

5631

Start / End Page

386 / 389

Related Subject Headings

Suicide, Attempted
Stress, Psychological
Serotonin Plasma Membrane Transport Proteins
Promoter Regions, Genetic
Probability
Polymorphism, Genetic
Nerve Tissue Proteins
Monoamine Oxidase
Membrane Transport Proteins
Membrane Glycoproteins