Scholars@Duke publication: Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.

Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.

Publication , Journal Article

Caspi, A; Sugden, K; Moffitt, TE; Taylor, A; Craig, IW; Harrington, H; McClay, J; Mill, J; Martin, J; Braithwaite, A; Poulton, R

Published in: Science (New York, N.Y.)

July 2003

Published version (DOI)

In a prospective-longitudinal study of a representative birth cohort, we tested why stressful experiences lead to depression in some people but not in others. A functional polymorphism in the promoter region of the serotonin transporter (5-HT T) gene was found to moderate the influence of stressful life events on depression. Individuals with one or two copies of the short allele of the 5-HT T promoter polymorphism exhibited more depressive symptoms, diagnosable depression, and suicidality in relation to stressful life events than individuals homozygous for the long allele. This epidemiological study thus provides evidence of a gene-by-environment interaction, in which an individual's response to environmental insults is moderated by his or her genetic makeup.

Duke Scholars

Author Avshalom Caspi Psychology & Neuroscience

Author Karen Sugden

Author Terrie E. Moffitt Psychology & Neuroscience

Published In

Science (New York, N.Y.)

DOI

10.1126/science.1083968

EISSN

1095-9203

ISSN

0036-8075

Publication Date

July 2003

Volume

301

Issue

5631

Start / End Page

386 / 389

Related Subject Headings

Suicide, Attempted
Stress, Psychological
Serotonin Plasma Membrane Transport Proteins
Promoter Regions, Genetic
Probability
Polymorphism, Genetic
Nerve Tissue Proteins
Monoamine Oxidase
Membrane Transport Proteins
Membrane Glycoproteins

Citation

APA

Chicago

ICMJE

MLA

NLM

Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., … Poulton, R. (2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science (New York, N.Y.), 301(5631), 386–389. https://doi.org/10.1126/science.1083968

Caspi, Avshalom, Karen Sugden, Terrie E. Moffitt, Alan Taylor, Ian W. Craig, HonaLee Harrington, Joseph McClay, et al. “Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.” Science (New York, N.Y.) 301, no. 5631 (July 2003): 386–89. https://doi.org/10.1126/science.1083968.

Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science (New York, NY). 2003 Jul;301(5631):386–9.

Caspi, Avshalom, et al. “Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.” Science (New York, N.Y.), vol. 301, no. 5631, July 2003, pp. 386–89. Epmc, doi:10.1126/science.1083968.

Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, Poulton R. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science (New York, NY). 2003 Jul;301(5631):386–389.

Published In

Science (New York, N.Y.)

DOI

10.1126/science.1083968

EISSN

1095-9203

ISSN

0036-8075

Publication Date

July 2003

Volume

301

Issue

5631

Start / End Page

386 / 389

Related Subject Headings

Suicide, Attempted
Stress, Psychological
Serotonin Plasma Membrane Transport Proteins
Promoter Regions, Genetic
Probability
Polymorphism, Genetic
Nerve Tissue Proteins
Monoamine Oxidase
Membrane Transport Proteins
Membrane Glycoproteins