Reduced kainic acid binding in rat hippocampal formation after limbic kindling.
Publication
, Journal Article
Savage, DD; Nadler, JV; McNamara, JO
Published in: Brain Res
December 3, 1984
The specific binding of [3H]kainic acid to hippocampal membranes was examined autoradiographically in rats kindled by tetanic stimulation of the amygdala or angular bundle. One day after the last of 3 class 4-5 kindled seizures, the specific binding of [3H]kainic acid in stratum lucidum of area CA3 was 47-61% less than in electrode-implanted unstimulated controls. Specific binding in the inner third of the dentate molecular layer was reduced to a lesser degree. These observations demonstrate that kainic acid receptors are down-regulated by kindling stimulation.
Duke Scholars
Published In
Brain Res
DOI
ISSN
0006-8993
Publication Date
December 3, 1984
Volume
323
Issue
1
Start / End Page
128 / 131
Location
Netherlands
Related Subject Headings
- Receptors, Neurotransmitter
- Receptors, Kainic Acid
- Rats, Inbred Strains
- Rats
- Pyrrolidines
- Neurology & Neurosurgery
- Male
- Limbic System
- Kindling, Neurologic
- Kainic Acid
Citation
APA
Chicago
ICMJE
MLA
NLM
Savage, D. D., Nadler, J. V., & McNamara, J. O. (1984). Reduced kainic acid binding in rat hippocampal formation after limbic kindling. Brain Res, 323(1), 128–131. https://doi.org/10.1016/0006-8993(84)90274-9
Savage, D. D., J. V. Nadler, and J. O. McNamara. “Reduced kainic acid binding in rat hippocampal formation after limbic kindling.” Brain Res 323, no. 1 (December 3, 1984): 128–31. https://doi.org/10.1016/0006-8993(84)90274-9.
Savage DD, Nadler JV, McNamara JO. Reduced kainic acid binding in rat hippocampal formation after limbic kindling. Brain Res. 1984 Dec 3;323(1):128–31.
Savage, D. D., et al. “Reduced kainic acid binding in rat hippocampal formation after limbic kindling.” Brain Res, vol. 323, no. 1, Dec. 1984, pp. 128–31. Pubmed, doi:10.1016/0006-8993(84)90274-9.
Savage DD, Nadler JV, McNamara JO. Reduced kainic acid binding in rat hippocampal formation after limbic kindling. Brain Res. 1984 Dec 3;323(1):128–131.
Published In
Brain Res
DOI
ISSN
0006-8993
Publication Date
December 3, 1984
Volume
323
Issue
1
Start / End Page
128 / 131
Location
Netherlands
Related Subject Headings
- Receptors, Neurotransmitter
- Receptors, Kainic Acid
- Rats, Inbred Strains
- Rats
- Pyrrolidines
- Neurology & Neurosurgery
- Male
- Limbic System
- Kindling, Neurologic
- Kainic Acid