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Kindling reduces sensitivity of CA3 hippocampal pyramidal cells to competitive NMDA receptor antagonists.

Publication ,  Journal Article
Nadler, JV; Thompson, MA; McNamara, JO
Published in: Neuropharmacology
February 1994

Kindling is a form of experimental epilepsy in which periodic electrical stimulation of a brain pathway induces a permanently hyperexcitable state. A previous study demonstrated that kindling enhances the sensitivity of hippocampal CA3 pyramidal cells to NMDA (N-methyl-D-aspartate), consistent with a greater expression of NMDA receptors. We have tested the possibility that kindling also changes the sensitivity of these neurons to competitive NMDA receptor antagonists. When depolarizing responses to NMDA were studied with a grease-gap preparation 1-5 months after the last evoked seizure, higher concentrations of competitive antagonist were required to reduce response amplitudes. Schild analysis yielded higher KD values for all three antagonists tested. This finding suggests that kindling provokes the expression by CA3 pyramidal cells of NMDA receptors with reduced affinity for competitive antagonists.

Duke Scholars

Published In

Neuropharmacology

DOI

ISSN

0028-3908

Publication Date

February 1994

Volume

33

Issue

2

Start / End Page

147 / 153

Location

England

Related Subject Headings

  • Receptors, N-Methyl-D-Aspartate
  • Rats, Sprague-Dawley
  • Rats
  • Pyramidal Cells
  • Neurology & Neurosurgery
  • Male
  • Kinetics
  • Kindling, Neurologic
  • Hippocampus
  • Dose-Response Relationship, Drug
 

Citation

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Nadler, J. V., Thompson, M. A., & McNamara, J. O. (1994). Kindling reduces sensitivity of CA3 hippocampal pyramidal cells to competitive NMDA receptor antagonists. Neuropharmacology, 33(2), 147–153. https://doi.org/10.1016/0028-3908(94)90001-9
Nadler, J. V., M. A. Thompson, and J. O. McNamara. “Kindling reduces sensitivity of CA3 hippocampal pyramidal cells to competitive NMDA receptor antagonists.Neuropharmacology 33, no. 2 (February 1994): 147–53. https://doi.org/10.1016/0028-3908(94)90001-9.
Nadler JV, Thompson MA, McNamara JO. Kindling reduces sensitivity of CA3 hippocampal pyramidal cells to competitive NMDA receptor antagonists. Neuropharmacology. 1994 Feb;33(2):147–53.
Nadler, J. V., et al. “Kindling reduces sensitivity of CA3 hippocampal pyramidal cells to competitive NMDA receptor antagonists.Neuropharmacology, vol. 33, no. 2, Feb. 1994, pp. 147–53. Pubmed, doi:10.1016/0028-3908(94)90001-9.
Nadler JV, Thompson MA, McNamara JO. Kindling reduces sensitivity of CA3 hippocampal pyramidal cells to competitive NMDA receptor antagonists. Neuropharmacology. 1994 Feb;33(2):147–153.
Journal cover image

Published In

Neuropharmacology

DOI

ISSN

0028-3908

Publication Date

February 1994

Volume

33

Issue

2

Start / End Page

147 / 153

Location

England

Related Subject Headings

  • Receptors, N-Methyl-D-Aspartate
  • Rats, Sprague-Dawley
  • Rats
  • Pyramidal Cells
  • Neurology & Neurosurgery
  • Male
  • Kinetics
  • Kindling, Neurologic
  • Hippocampus
  • Dose-Response Relationship, Drug