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CD4+Thy1- thymocytes with a Th-type 2 cytokine response.

Publication ,  Journal Article
Cerasoli, DM; Kelsoe, G; Sarzotti, M
Published in: Int Immunol
January 2001

We have identified a small subset of CD3(+), CD4(+), CD8(-) thymocytes that do not express Thy1 (CD90). This Thy1(-) subset represents 1-3.7% of the total number of thymocytes in a naive mouse. CD4(+)Thy1(-) thymocytes express high levels of CD3, intermediate to high levels of heat-stable antigen (HSA), and low levels of CD25, CD45RB, CD69, CD44 and CD62L. They produce high titers of IL-4 and no IFN-gamma upon stimulation in vitro, a response characteristic of T(h)2 cells. In the thymi of mice infected neonatally with a high dose of the retrovirus Cas-Br-E MuLV, the frequency of CD4(+)Thy1(-) cells increased approximately 10-fold. High-dose virus infection resulted in decreased HSA and increased CD44 expression on CD4(+)Thy1(-) cells relative to cells from naive mice. CD4(+)Thy1(-) cells from high-dose infected mice also secreted IL-4 and not IFN-gamma upon in vitro stimulation. We previously reported that infection of newborn mice with a high dose of murine retrovirus results in the induction of a non-protective anti-viral T(h)2 T cell response; CD4(+)Thy1(-) thymocytes with a T(h)2-like cytokine profile may play a role in determining the cytokine bias of this anti-viral response.

Duke Scholars

Published In

Int Immunol

DOI

ISSN

0953-8178

Publication Date

January 2001

Volume

13

Issue

1

Start / End Page

75 / 83

Location

England

Related Subject Headings

  • Tumor Virus Infections
  • Thymus Gland
  • Thy-1 Antigens
  • Th2 Cells
  • T-Lymphocyte Subsets
  • Retroviridae Infections
  • Mice
  • Lymphocyte Activation
  • Leukemia, Experimental
  • Leukemia Virus, Murine
 

Citation

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Cerasoli, D. M., Kelsoe, G., & Sarzotti, M. (2001). CD4+Thy1- thymocytes with a Th-type 2 cytokine response. Int Immunol, 13(1), 75–83. https://doi.org/10.1093/intimm/13.1.75
Cerasoli, D. M., G. Kelsoe, and M. Sarzotti. “CD4+Thy1- thymocytes with a Th-type 2 cytokine response.Int Immunol 13, no. 1 (January 2001): 75–83. https://doi.org/10.1093/intimm/13.1.75.
Cerasoli DM, Kelsoe G, Sarzotti M. CD4+Thy1- thymocytes with a Th-type 2 cytokine response. Int Immunol. 2001 Jan;13(1):75–83.
Cerasoli, D. M., et al. “CD4+Thy1- thymocytes with a Th-type 2 cytokine response.Int Immunol, vol. 13, no. 1, Jan. 2001, pp. 75–83. Pubmed, doi:10.1093/intimm/13.1.75.
Cerasoli DM, Kelsoe G, Sarzotti M. CD4+Thy1- thymocytes with a Th-type 2 cytokine response. Int Immunol. 2001 Jan;13(1):75–83.
Journal cover image

Published In

Int Immunol

DOI

ISSN

0953-8178

Publication Date

January 2001

Volume

13

Issue

1

Start / End Page

75 / 83

Location

England

Related Subject Headings

  • Tumor Virus Infections
  • Thymus Gland
  • Thy-1 Antigens
  • Th2 Cells
  • T-Lymphocyte Subsets
  • Retroviridae Infections
  • Mice
  • Lymphocyte Activation
  • Leukemia, Experimental
  • Leukemia Virus, Murine