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Fetal nicotine exposure ablates the ability of postnatal nicotine challenge to release norepinephrine from rat brain regions.

Publication ,  Journal Article
Seidler, FJ; Levin, ED; Lappi, SE; Slotkin, TA
Published in: Brain Res Dev Brain Res
October 23, 1992

Exposure of the fetus to nicotine is known to affect the function of noradrenergic pathways in the central nervous system. In the current study, synaptic mechanisms underlying the functional defects were evaluated in the offspring of pregnant rats given nicotine infusions of 2 mg/kg/day throughout gestation, administered by osmotic minipumps. At 30 days postpartum, norepinephrine levels in brain regions of the offspring were significantly reduced. More importantly, acute challenge with either 0.1 mg/kg or 0.3 mg/kg of nicotine evoked significant norepinephrine release from brain regions of control animals, but failed to do so in the fetal nicotine cohort. These results suggest that prenatal exposure to nicotine produces a deficit in subsequent noradrenergic responsiveness, deficits which may participate in behavioral and neuroendocrine abnormalities.

Duke Scholars

Published In

Brain Res Dev Brain Res

DOI

ISSN

0165-3806

Publication Date

October 23, 1992

Volume

69

Issue

2

Start / End Page

288 / 291

Location

Netherlands

Related Subject Headings

  • alpha-Methyltyrosine
  • Rats, Sprague-Dawley
  • Rats
  • Pregnancy
  • Norepinephrine
  • Nicotine
  • Neurology & Neurosurgery
  • Methyltyrosines
  • Mesencephalon
  • Maternal-Fetal Exchange
 

Citation

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MLA
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Seidler, F. J., Levin, E. D., Lappi, S. E., & Slotkin, T. A. (1992). Fetal nicotine exposure ablates the ability of postnatal nicotine challenge to release norepinephrine from rat brain regions. Brain Res Dev Brain Res, 69(2), 288–291. https://doi.org/10.1016/0165-3806(92)90170-2
Seidler, F. J., E. D. Levin, S. E. Lappi, and T. A. Slotkin. “Fetal nicotine exposure ablates the ability of postnatal nicotine challenge to release norepinephrine from rat brain regions.Brain Res Dev Brain Res 69, no. 2 (October 23, 1992): 288–91. https://doi.org/10.1016/0165-3806(92)90170-2.
Seidler FJ, Levin ED, Lappi SE, Slotkin TA. Fetal nicotine exposure ablates the ability of postnatal nicotine challenge to release norepinephrine from rat brain regions. Brain Res Dev Brain Res. 1992 Oct 23;69(2):288–91.
Seidler, F. J., et al. “Fetal nicotine exposure ablates the ability of postnatal nicotine challenge to release norepinephrine from rat brain regions.Brain Res Dev Brain Res, vol. 69, no. 2, Oct. 1992, pp. 288–91. Pubmed, doi:10.1016/0165-3806(92)90170-2.
Seidler FJ, Levin ED, Lappi SE, Slotkin TA. Fetal nicotine exposure ablates the ability of postnatal nicotine challenge to release norepinephrine from rat brain regions. Brain Res Dev Brain Res. 1992 Oct 23;69(2):288–291.
Journal cover image

Published In

Brain Res Dev Brain Res

DOI

ISSN

0165-3806

Publication Date

October 23, 1992

Volume

69

Issue

2

Start / End Page

288 / 291

Location

Netherlands

Related Subject Headings

  • alpha-Methyltyrosine
  • Rats, Sprague-Dawley
  • Rats
  • Pregnancy
  • Norepinephrine
  • Nicotine
  • Neurology & Neurosurgery
  • Methyltyrosines
  • Mesencephalon
  • Maternal-Fetal Exchange