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Prenatal exposure to nicotine impairs nervous system development at a dose which does not affect viability or growth.

Publication ,  Journal Article
Navarro, HA; Seidler, FJ; Schwartz, RD; Baker, FE; Dobbins, SS; Slotkin, TA
Published in: Brain Res Bull
September 1989

Prenatal exposure to high doses of nicotine (greater than 6 mg/kg/day) via maternal infusions has been shown to impair nervous system development and to decrease viability and growth. In the current study, we have examined the effects of infusing pregnant rats with 2 mg/kg of nicotine per day from gestational days 4 through 20. At this lower dose, there was neither interference with maternal weight gain nor any increase in resorption rate. Intrauterine and postnatal growth was maintained at normal or supranormal rates in the exposed offspring. Nevertheless, sufficient nicotine penetrated the fetal brain to cause persistent alterations in [3H]nicotine binding sites, abnormalities of cellular development [assessed by measurements of ornithine decarboxylase (ODC) activity and deoxyribonucleic acid (DNA)], and impairment of development of peripheral noradrenergic projections (assessed by kidney norepinephrine levels); in each case, the neural alterations were virtually equivalent to those obtained previously at the higher, growth-suppressant dosage. These findings indicate that growth impairment alone is insufficient to predict the adverse effects of nicotine on development.

Duke Scholars

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Published In

Brain Res Bull

DOI

ISSN

0361-9230

Publication Date

September 1989

Volume

23

Issue

3

Start / End Page

187 / 192

Location

United States

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Ornithine Decarboxylase Inhibitors
  • Norepinephrine
  • Nicotine
  • Neurology & Neurosurgery
  • Kidney
  • Growth
 

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Navarro, H. A., Seidler, F. J., Schwartz, R. D., Baker, F. E., Dobbins, S. S., & Slotkin, T. A. (1989). Prenatal exposure to nicotine impairs nervous system development at a dose which does not affect viability or growth. Brain Res Bull, 23(3), 187–192. https://doi.org/10.1016/0361-9230(89)90146-9
Navarro, H. A., F. J. Seidler, R. D. Schwartz, F. E. Baker, S. S. Dobbins, and T. A. Slotkin. “Prenatal exposure to nicotine impairs nervous system development at a dose which does not affect viability or growth.Brain Res Bull 23, no. 3 (September 1989): 187–92. https://doi.org/10.1016/0361-9230(89)90146-9.
Navarro HA, Seidler FJ, Schwartz RD, Baker FE, Dobbins SS, Slotkin TA. Prenatal exposure to nicotine impairs nervous system development at a dose which does not affect viability or growth. Brain Res Bull. 1989 Sep;23(3):187–92.
Navarro, H. A., et al. “Prenatal exposure to nicotine impairs nervous system development at a dose which does not affect viability or growth.Brain Res Bull, vol. 23, no. 3, Sept. 1989, pp. 187–92. Pubmed, doi:10.1016/0361-9230(89)90146-9.
Navarro HA, Seidler FJ, Schwartz RD, Baker FE, Dobbins SS, Slotkin TA. Prenatal exposure to nicotine impairs nervous system development at a dose which does not affect viability or growth. Brain Res Bull. 1989 Sep;23(3):187–192.

Published In

Brain Res Bull

DOI

ISSN

0361-9230

Publication Date

September 1989

Volume

23

Issue

3

Start / End Page

187 / 192

Location

United States

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Ornithine Decarboxylase Inhibitors
  • Norepinephrine
  • Nicotine
  • Neurology & Neurosurgery
  • Kidney
  • Growth